Results 121 to 130 of about 751,138 (168)
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1993
Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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Evolution of Viral DNA-Dependent DNA Polymerases
Virus Genes, 1998DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3'-5'-exonuclease, and other replication proteins. All known viral Pol belong to family A and family B Pol. Common to
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Nuclear targeting of viral and non-viral DNA
Expert Opinion on Drug Delivery, 2009The nuclear envelope presents a major barrier to transgene delivery and expression using a non-viral vector. Virus is capable of overcoming the barrier to deliver their genetic materials efficiently into the nucleus by virtue of the specialized protein components with the unique amino acid sequences recognizing cellular nuclear transport machinery ...
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Initiation of Viral DNA Replication
1988Publisher Summary This chapter focuses on the mechanisms involved in initiation of animal virus DNA replication. This step is of fundamental importance because it represents the central point of control of the replication process. Two of the best-characterized viruses, adenovirus and SV40, are discussed as examples of viruses that normally multiply ...
T J, Kelly, M S, Wold, J, Li
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An Error-Prone Viral DNA Ligase
Biochemistry, 2005Our recent demonstration that DNA polymerase X (Pol X), the DNA repair polymerase encoded by the African swine fever virus (ASFV), is extremely error prone during single-nucleotide gap filling led us to hypothesize that it might contribute to genetic variability in ASFV.
Brandon J, Lamarche +2 more
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Production of Non Viral DNA Vectors
Current Gene Therapy, 2010After some decades of research, development and first clinical approaches to use DNA vectors in gene therapy, cell therapy and DNA vaccination, the requirements for the pharmaceutical manufacturing of gene vectors has improved significantly step by step.
Martin, Schleef +6 more
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2001
Update on antiviral DNA vaccine research (1998-2000) optimization strategies for DNA vaccines relative potency of cellular and humoral immune responses induced by DNA vaccination improving DNA vaccines targeting viral infection alphavirus vectors - applications for DNA vaccine production and gene expression plasmid DNA vaccines - investigation of ...
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Update on antiviral DNA vaccine research (1998-2000) optimization strategies for DNA vaccines relative potency of cellular and humoral immune responses induced by DNA vaccination improving DNA vaccines targeting viral infection alphavirus vectors - applications for DNA vaccine production and gene expression plasmid DNA vaccines - investigation of ...
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2014
Adenoviren verursachen im Kindesalter Krankheiten der Atemwege und des Darms, aber auch Krankheiten der Harnwege, der Lymphorgane, kardiologische und neurologische Manifestationen werden beobachtet. Einige typische Krankheitsbilder konnen klinisch diagnostiziert werden.
Johannes Forster +2 more
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Adenoviren verursachen im Kindesalter Krankheiten der Atemwege und des Darms, aber auch Krankheiten der Harnwege, der Lymphorgane, kardiologische und neurologische Manifestationen werden beobachtet. Einige typische Krankheitsbilder konnen klinisch diagnostiziert werden.
Johannes Forster +2 more
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DNA Viral Infections Complicating Lung Transplantation
Seminars in Respiratory and Critical Care Medicine, 2013DNA viruses with potential to cause complications after lung transplantation include the human Herpesviridae family consisting of cytomegalovirus (CMV), herpes simplex virus 1 and 2 (HSV-1, -2), varicella-zoster virus (VZV), human herpesvirus 6, 7, and 8 (HHV-6, -7, -8), and Epstein-Barr virus (EBV); the Polyomaviridae family consisting of BK virus and
Nina M, Clark +5 more
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Conformational Properties of Some Viral DNAs
European Journal of Biochemistry, 1974Oriented films of bacteriophage DNAs of low and intermediate (G + C) content and of different chemical composition were investigated by infrared linear dichroism: PBS1, DNA (28% G + C, uracil replaces thymine), T4, DNA (34%, G + C, glucosylated), T4* DNA (34% G + C, unglucosylated), T5, DNA (39% G + C).
P, Champeil, J, Brahms
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