Results 161 to 170 of about 2,726,530 (186)

Production of Non Viral DNA Vectors

Current Gene Therapy, 2010
After some decades of research, development and first clinical approaches to use DNA vectors in gene therapy, cell therapy and DNA vaccination, the requirements for the pharmaceutical manufacturing of gene vectors has improved significantly step by step.
Martin, Schleef, Markus, Blaesen, Marco, Schmeer, Ruth, Baier, Corinne, Marie, George, Dickson, Daniel, Scherman   +6 more
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DNA Probes for Viral Diagnosis

1992
Great excitement has surrounded the development of molecular hybridization techniques for viruses because of the potential of nucleic acid probes as diagnostic reagents. The need for rapid and accurate viral diagnosis has become particularly pressing with the recent availability of numerous drugs which have been clinically proven as effective in ...
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An Error-Prone Viral DNA Ligase

Biochemistry, 2005
Our recent demonstration that DNA polymerase X (Pol X), the DNA repair polymerase encoded by the African swine fever virus (ASFV), is extremely error prone during single-nucleotide gap filling led us to hypothesize that it might contribute to genetic variability in ASFV.
Brandon J, Lamarche, Alexander K, Showalter, Ming-Daw, Tsai   +2 more
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Methylation of viral DNA in Vivo and in Vitro

Virology, 1979
Abstract Methylation of herpesvirus saimiri DNA and adenovirus type 5 DNA was examined by labelling with [6-3H]uridine and [2-3H]adenosine and separating the bases by thin layer chromatography. The number of methyl groups was less than one per genome in both DNAs, indicating that these viral DNAs are not substrates for methylation in vivo.
U, von Acken, D, Simon, F, Grunert, H P, Döring, H, Kröger   +4 more
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Packaging of DNA origami in viral capsids

Nanoscale, 2019
DNA origami in self-assembled SV40 capsid, a new type of encapsulation substrate for medical applications.
Idit Kopatz, Ran Zalk, Yael Levi-Kalisman, Efrat Zlotkin-Rivkin, Gabriel A. Frank, Stanislav Kler   +5 more
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Mechanochemistry of a Viral DNA Packaging Motor

Journal of Molecular Biology, 2010
The pentameric ATPase motor gp16 packages double-stranded DNA into the bacteriophage phi29 virus capsid. On the basis of the results of single-molecule experimental studies, we propose a push and roll mechanism to explain how the packaging motor translocates the DNA in bursts of four 2.5 bp power strokes, while rotating the DNA. In this mechanism, each
Jin, Yu, Jeffrey, Moffitt, Craig L, Hetherington, Carlos, Bustamante, George, Oster   +4 more
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Safety of Viral DNA in Biological Products

Biologicals, 1998
Data from studies of the infectivity of DNA injected directly into laboratory animals are used to estimate the potential infectivity risk of residual DNA in biological products. The potential for some novel products to contain infectious quantities of residual cellular DNA is discussed, and further study of this subject is suggested.
P R, Krause, A M, Lewis
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Conformational Properties of Some Viral DNAs

European Journal of Biochemistry, 1974
Oriented films of bacteriophage DNAs of low and intermediate (G + C) content and of different chemical composition were investigated by infrared linear dichroism: PBS1, DNA (28% G + C, uracil replaces thymine), T4, DNA (34%, G + C, glucosylated), T4* DNA (34% G + C, unglucosylated), T5, DNA (39% G + C).
P, Champeil, J, Brahms
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Viral DNA Vaccines

2001
Update on antiviral DNA vaccine research (1998-2000) optimization strategies for DNA vaccines relative potency of cellular and humoral immune responses induced by DNA vaccination improving DNA vaccines targeting viral infection alphavirus vectors - applications for DNA vaccine production and gene expression plasmid DNA vaccines - investigation of ...
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Characterization of human papovavirus RFV: Use of iodinated viral DNA to detect viral DNA sequences in cellular DNA

Virology, 1977
Abstract The amount of viral DNA present in a viral transformed cell line has been determined using saturation reassociation of cellular DNA and 125 I-labeled viral DNA. The virus, RFV, is a new human papovavirus which was used to transform hamster embryo cells in vitro .
R, Miao, R M, Dougherty
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