Results 171 to 180 of about 947,078 (263)

Digital Bioassays on the Slipchip Microfluidic Devices

Advanced Sensor Research, EarlyView.
This review summarizes recent advances in SlipChip‐based digital bioassays, highlighting their simple “load and slip” operation for fluid partitioning which eliminate the need for sophisticated fluidic systems. Applications include digital nucleic acid analysis, digital protein analysis and single‐cell analysis, demonstrating the platform‘s potential ...
Qingqing Luo, Ziqing Yu, Weiyuan Lyu, Yang Luo, Lei Xu, Feng Shen   +5 more
wiley   +1 more source

Parvoviruses NS1 oncolytic attributes: mechanistic insights and synergistic anti-tumor therapeutic strategies. [PDF]

Front Microbiol
Haseeb A, Yousaf W, Cao Z, Fan K, Sun N, Sun P, Sun Y, Yang H, Yin W, Zhang H, Zhang Z, Zhong J, Wang J, Li H.   +13 more
europepmc   +1 more source

From Lab to Market: Paper‐Based CRISPR Diagnostics and Commercialization Pathways

Advanced Sensor Research, EarlyView.
Paper‐based CRISPR diagnostics represents one of the most widely commercialized CRISPR assay technologies, yet challenges remain for broader point‐of‐care use. Abstract The global health landscape is continually challenged by infectious diseases that can swiftly escalate into pandemics, underscoring the need for rapid, accurate, and cost‐effective ...
Selen Dalgan, Qingshan Wei
wiley   +1 more source

Response to Yang et al. [PDF]

Clin Transl Gastroenterol
Zhou T, Shu M, Du Y, Cai W.
europepmc   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

An invertebrate NLR recognizes viral nucleic acids and balances the antiviral signaling pathway through interaction with STING and Cyclophilin A. [PDF]

PLoS Pathog
Li S, Li X, Sun M, Li F.
europepmc   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Enhanced Doxorubicin Cytotoxicity on Breast Cancer Spheroids by Aptamer Targeted Co‐Delivery with Hyaluronidase

Advanced Therapeutics, EarlyView.
Breast cancer is one of the most prevalent solid tumors in women. Doxorubicin is loaded mesoporous silica nanoparticles, capped with HER2‐specific aptamers, and the particle surface is functionalized with hyaluronidase. This dual‐functionalized nanocarrier system offers a promising solution for the drug resistance by solid tumors.
Murat Kavruk, Dide Su Demirel, Farzaneh Bonyadi, Buket Çakmak Güner, Ali Doğan Dursun, Cekdar Vakifahmetoglu, Bilge Güvenç Tuna, Uğur Şahin, Veli Cengiz Ozalp   +8 more
wiley   +1 more source

HBV-miR-3 and cGAS-STING axis: a new frontier in hepatitis B therapy. [PDF]

Front Cell Infect Microbiol
Hua C, Aftab S, Baloch Z.
europepmc   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source