Results 251 to 260 of about 548,105 (272)
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DNA Probes for Viral Diagnosis
1992Great excitement has surrounded the development of molecular hybridization techniques for viruses because of the potential of nucleic acid probes as diagnostic reagents. The need for rapid and accurate viral diagnosis has become particularly pressing with the recent availability of numerous drugs which have been clinically proven as effective in ...
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An Error-Prone Viral DNA Ligase
Biochemistry, 2005Our recent demonstration that DNA polymerase X (Pol X), the DNA repair polymerase encoded by the African swine fever virus (ASFV), is extremely error prone during single-nucleotide gap filling led us to hypothesize that it might contribute to genetic variability in ASFV.
and Alexander K. Showalter +2 more
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Packaging of DNA origami in viral capsids
Nanoscale, 2019DNA origami in self-assembled SV40 capsid, a new type of encapsulation substrate for medical applications.
Idit Kopatz +5 more
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A nuclear sensor of viral DNA?
Science, 2019Immune Signaling A signaling pathway in eukaryotes known as cGAS–STING recognizes the presence of cytosolic DNA, which alerts the immune system to viral infection or cellular damage. However, the majority of DNA viruses direct their genomic DNA into nuclei, suggesting that nuclear-specific sensing is also needed. L. Wang et al.
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2014
Adenoviren verursachen im Kindesalter Krankheiten der Atemwege und des Darms, aber auch Krankheiten der Harnwege, der Lymphorgane, kardiologische und neurologische Manifestationen werden beobachtet. Einige typische Krankheitsbilder konnen klinisch diagnostiziert werden.
Volker Schuster +2 more
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Adenoviren verursachen im Kindesalter Krankheiten der Atemwege und des Darms, aber auch Krankheiten der Harnwege, der Lymphorgane, kardiologische und neurologische Manifestationen werden beobachtet. Einige typische Krankheitsbilder konnen klinisch diagnostiziert werden.
Volker Schuster +2 more
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Conformational Properties of Some Viral DNAs
European Journal of Biochemistry, 1974Oriented films of bacteriophage DNAs of low and intermediate (G + C) content and of different chemical composition were investigated by infrared linear dichroism: PBS1, DNA (28% G + C, uracil replaces thymine), T4, DNA (34%, G + C, glucosylated), T4* DNA (34% G + C, unglucosylated), T5, DNA (39% G + C).
P. Champell, J. Brahms
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Mechanochemistry of a Viral DNA Packaging Motor
Journal of Molecular Biology, 2010The pentameric ATPase motor gp16 packages double-stranded DNA into the bacteriophage phi29 virus capsid. On the basis of the results of single-molecule experimental studies, we propose a push and roll mechanism to explain how the packaging motor translocates the DNA in bursts of four 2.5 bp power strokes, while rotating the DNA. In this mechanism, each
Jeffrey R. Moffitt +4 more
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1983
Publisher Summary The small size and relative homogeneity of viral DNA facilitates its isolation and the detailed characterization of its physical and genetic properties. As the virus and/or its nucleic acid genome can usually be purified to homogeneity, it is possible to eliminate or control indirect effects in the course of treatment. The viral DNA
Martine Defais +2 more
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Publisher Summary The small size and relative homogeneity of viral DNA facilitates its isolation and the detailed characterization of its physical and genetic properties. As the virus and/or its nucleic acid genome can usually be purified to homogeneity, it is possible to eliminate or control indirect effects in the course of treatment. The viral DNA
Martine Defais +2 more
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Safety of Viral DNA in Biological Products
Biologicals, 1998Data from studies of the infectivity of DNA injected directly into laboratory animals are used to estimate the potential infectivity risk of residual DNA in biological products. The potential for some novel products to contain infectious quantities of residual cellular DNA is discussed, and further study of this subject is suggested.
Philip R. Krause, Andrew M. Lewis
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Organization of type C viral DNA sequences endogenous to baboons: analysis with cloned viral DNA
Journal of Virology, 1982Unintegrated linear and circular forms of baboon endogenous type C virus M7 DNA were prepared from M7-infected cells by chromatography on hydroxyapatite columns, and the circular DNAs were purified in cesium chloride-ethidium bromide equilibrium density gradients. The circular DNAs were linearized by digestion with EcoRI, which had a unique site on the
N Battula, G L Hager, G J Todaro
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