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Viral Vaccines and Residual Cellular DNA
Biologicals, 1995The acceptability of viral vaccines manufactured in culture of continuous cell lines opened the way to a new technology of vaccine preparation. The large scale cultivation of continuous cell lines contributed greatly to the improvement of the safety and the consistency of viral vaccines.
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Branched DNA for Quantification of Viral LOAD
Immunological Investigations, 1997This is a summary of a presentation made at the 13th International Convocation on Immunology. Nucleic acids in patient samples can be quantified directly using a solid phase nucleic acid hybridization assay based on branched DNA (bDNA) signal amplification technology.
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Evolution of viral DNA-dependent DNA polymerases.
Virus genes, 1998DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3'-5'-exonuclease, and other replication proteins. All known viral Pol belong to family A and family B Pol. Common to
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Integration of Viral DNA into the Host Genome
1975Animal viruses can interact with their host cells in different ways: (1) The virus can actively replicate and finally destroy the cell in a lytic or productive infection. (2) The infection can become abortive or non-productive and lead to the apparent or inapparent persistence or the eventual loss of the viral genome.
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DNA Sequencing of Viral Genomes
1979In his book Biochemistry Lehninger (1970) illustrated the complexity of the genetic material by devoting a full page to closely spaced arrays of A, G, C, and T letters, calling this “an imaginary base sequence for the chromosome of bacteriophage oX174” and pointing out that this is one of the smallest DNA genomes known.
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The Anatomy of Viral DNA Molecules
Annual Review of Biochemistry, 1967L A MacHattie, C A Thomas
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Viral Genomic DNA Packaging Machinery
Tailed double-stranded DNA bacteriophage employs a protein terminase motor to package their genome into a preformed protein shell-a system shared with eukaryotic dsDNA viruses such as herpesviruses. DNA packaging motor proteins represent excellent targets for antiviral therapy, with Letermovir, which binds Cytomegalovirus terminase, already licensed asDorothy E D P, Hawkins +2 more
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Transfer of viral DNA into liposomes
Biology of the Cell, 1999Laure Plançon +3 more
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