Results 281 to 290 of about 3,750,929 (346)

Meeting Summary for Keystone Symposia on HIV Cure: Antiretroviral Therapy (ART)-Free Control of HIV Infection in Durban, South Africa, 2025. [PDF]

Pathog Immun
Tanaka K, Chikowore TJB, Deeks SG, Estes JD, Ho YC, Jiang S, Lee MJ, Li C, Machinda A, Martins M, Mdletshe P, Ndhlovu ZM, Neogi U, Ott MM, Rasmussen TA, Reddy K, Rutishauser RL, Farrell-Sherman A, Tiemessen CT, Voss JE, Kityo C, Lewin SR, Ndung'u T, McCune JM.   +23 more
europepmc   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, EarlyView.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Unraveling the Inactivation Mechanisms of Human Adenovirus 2 in Sunlight Disinfection: Synergism between Direct and Indirect Pathways. [PDF]

Environ Sci Technol
Shin S, Lee Y, Kohn T.
europepmc   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Human Polyomavirus BK Genome Analysis in BKPyV Induced Rodent Cell Lines. [PDF]

Microbiologyopen
Shioda S, Kasai F, Ozawa M, Ohtani A, Iemura M, Watanabe K, Kohara A.   +6 more
europepmc   +1 more source

FBXO44 Regulates FOXP1 Degradation Through AURKA‐Dependent Phosphorylation to Promote Colorectal Cancer Progression

Advanced Science, EarlyView.
FBXO44 promotes colorectal cancer progression by targeting FOXP1 for ubiquitin‐mediated degradation. This study reveals a phosphorylation‐dependent mechanism involving AURKA and highlights the FBXO44/FOXP1/Cyclin E2 axis as a potential therapeutic target in colorectal cancer.
Hongxu Nie, Hengjie Xu, Sheng Yang, Chuanxin Tian, Tuo Wang, Chi Jin, Zhihao Chen, Xiaowei Wang, Junwei Tang, Yifei Feng, Yueming Sun   +10 more
wiley   +1 more source

Rapid clearance of inducible HIV-1 proviruses after initiation of antiretroviral therapy. [PDF]

PLoS Pathog
Puertas MC, Bailón L, Urrea V, García-Guerrero MC, Alarcón-Soto Y, Rivero A, Mothe B, Moltó J, Martinez-Picado J, DUALITY study group.   +9 more
europepmc   +1 more source

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

The dynamic interactions between virus infections and nonsense-mediated decay. [PDF]

Hum Mol Genet
van der Klugt T, van Gent M.
europepmc   +1 more source

Baculovirus 25K hijacks host UAP56 to facilitate nuclear export of viral mRNA in insect cells. [PDF]

J Virol
Xiao S, Guo H, Liu J, Wei L, Yang Q, Xie E, Wang B, Xia Q, Jiang L.   +8 more
europepmc   +1 more source