Results 291 to 300 of about 3,781,819 (347)
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Nature, 1997
Many viruses carry their genetic information in the form of RNA, and with the exception of the retroviruses replicate entirely through RNA intermediates. One such virus is lymphocytic choriomeningitis virus, which has now been caught red-handed in the act of illicit synthesis of DNA — seemingly through the agency of the reverse transcriptase enzyme ...
Robin A. Weiss, Paul Kellam
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Many viruses carry their genetic information in the form of RNA, and with the exception of the retroviruses replicate entirely through RNA intermediates. One such virus is lymphocytic choriomeningitis virus, which has now been caught red-handed in the act of illicit synthesis of DNA — seemingly through the agency of the reverse transcriptase enzyme ...
Robin A. Weiss, Paul Kellam
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Initiation of Viral DNA Replication
1988Publisher Summary This chapter focuses on the mechanisms involved in initiation of animal virus DNA replication. This step is of fundamental importance because it represents the central point of control of the replication process. Two of the best-characterized viruses, adenovirus and SV40, are discussed as examples of viruses that normally multiply ...
T J, Kelly, M S, Wold, J, Li
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Quantitation of bovine papilloma viral DNA in viral-induced tumors
Journal of Virology, 1976Bovine papilloma virus (BPV) DNA was labeled in vitro under conditions of repair synthesis and subsequently used as a "probe" in DNA-DNA reassociation studies to detect BPV-specific DNA sequences in a viral-induced calf meningioma and hamster fibroma.
W D, Lancaster, C, Olson, W, Meinke
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Evolution of Viral DNA-Dependent DNA Polymerases
Virus Genes, 1998DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3'-5'-exonuclease, and other replication proteins. All known viral Pol belong to family A and family B Pol. Common to
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Methylation of viral DNA in Vivo and in Vitro
Virology, 1979Abstract Methylation of herpesvirus saimiri DNA and adenovirus type 5 DNA was examined by labelling with [6-3H]uridine and [2-3H]adenosine and separating the bases by thin layer chromatography. The number of methyl groups was less than one per genome in both DNAs, indicating that these viral DNAs are not substrates for methylation in vivo.
U, von Acken +4 more
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Packaging of DNA origami in viral capsids
Nanoscale, 2019DNA origami in self-assembled SV40 capsid, a new type of encapsulation substrate for medical applications.
Idit Kopatz +5 more
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DNA Probes for Viral Diagnosis
1992Great excitement has surrounded the development of molecular hybridization techniques for viruses because of the potential of nucleic acid probes as diagnostic reagents. The need for rapid and accurate viral diagnosis has become particularly pressing with the recent availability of numerous drugs which have been clinically proven as effective in ...
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An Error-Prone Viral DNA Ligase
Biochemistry, 2005Our recent demonstration that DNA polymerase X (Pol X), the DNA repair polymerase encoded by the African swine fever virus (ASFV), is extremely error prone during single-nucleotide gap filling led us to hypothesize that it might contribute to genetic variability in ASFV.
Brandon J, Lamarche +2 more
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1993
Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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Abstract During the last decade considerable interest has focused upon the mechanisms by which the genomes of DNA animal viruses are replicated. These studies provide information relevant not only to our understanding of viral growth and potential strategies for intervention, but also to processes occurring during the replication of ...
Nigel D Stow, Ronald T Hay
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Production of Non Viral DNA Vectors
Current Gene Therapy, 2010After some decades of research, development and first clinical approaches to use DNA vectors in gene therapy, cell therapy and DNA vaccination, the requirements for the pharmaceutical manufacturing of gene vectors has improved significantly step by step.
Martin, Schleef +6 more
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