Results 71 to 80 of about 548,105 (272)
Viral replication organelles: the highly complex and programmed replication machinery
Frontiers in MicrobiologyViral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication.
Hao Deng +7 more
doaj +1 more source
Scientific Reports, 2023 In this study, non-electrically controlled SalivaDirect loop-mediated isothermal amplification (NEC-SD-LAMP), which can detect infections by amplifying viral DNA expression in saliva without using electrical control systems, was developed. By this method,
Yusuke Kimura, Masashi Ikeuchi
doaj +1 more source
A comprehensive stochastic computational model of HIV infection from DNA integration to viral burst [PDF]
arXiv, 2017 Multiple mechanisms in the HIV lifecycle play a role in its ability to evade therapy and become a chronic, difficult-to-treat infection. Within its major cellular target, the activated T cell, many steps occur between viral entry and viral burst, including reverse transcription of viral RNA, integration of the viral DNA in the host genome, viral ...
arxiv
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Packaging of viral RNAs in virions of adenoviruses
Virology Journal, 2009 Earlier, we detected viral RNAs packaged in the porcine adenovirus (PAdV) -3 virions. Using Southern blot analysis, we further demonstrated that the viral RNAs were predominantly packaged in CsCl purified mature capsids (containing viral genome) than ...
Xing Li, Tikoo Suresh K
doaj +1 more source
Biological Consequences of Tightly Bent DNA: The Other Life of a Macromolecular Celebrity [PDF]
arXiv, 2006 The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length.
arxiv
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Molecular Oncology, EarlyView.Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki +2 more
wiley +1 more source
Different patterns of HIV-1 DNA after therapy discontinuation
BMC Infectious Diseases, 2005 Background By persisting in infected cells for a long period of time, proviral HIV-1 DNA can represent an alternative viral marker to RNA viral load during the follow-up of HIV-1 infected individuals.
Ghinelli Florio +5 more
doaj +1 more source
Nature Communications, 2023 The H3 methyltransferases ATXR5 and ATXR6 deposit H3.1K27me1 to heterochromatin to prevent genomic instability and transposon re-activation. Here, we report that atxr5 atxr6 mutants display robust resistance to Geminivirus.
Zhen Wang +14 more
doaj +1 more source
The twisted circular form of polyoma viral DNA. [PDF]
Proceedings of the National Academy of Sciences, 1965 The major part of the DNA from polyoma virus has been shown to consist of circular base-paired duplex molecules without chain ends.1–3 The intertwined circular form accounts for the ease of renaturation4 of this DNA and the failure of the strands to separate in strand-separating solvents.1 ...
Vinograd, J. +4 more
openaire +4 more sources