Viral oncoproteins target the DNA methyltransferases [PDF]
Oncogene, 2006 Small DNA tumour viruses have evolved a number of mechanisms to drive nondividing cells into S phase. Virally encoded oncoproteins such as adenovirus E1A and human papillomavirus (HPV) E7 can bind an array of cellular proteins to override proliferation arrest. The DNA methyltransferase Dnmt1 is the major mammalian enzyme responsible for maintaining CpG
Burgers, T +7 more
openaire +4 more sources
Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections
Immunity & Ageing, 2019 Background T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood.
Yingjie Ji +15 more
doaj +1 more source
Clinical Case Reports, 2021 We recently identified and treated a rare case of oral focal epithelial hyperplasia (FEH) in an adult patient with chronic graft‐vs‐host disease. This is the first report linking KTP laser therapy to successful long‐term treatment HPV32 FEH.
Joe Truong Nguyen +6 more
doaj +1 more source
Nuclear Import of Viral DNA Genomes [PDF]
Traffic, 2003 The genomes of many viruses traffic into the nucleus, where they are either integrated into host chromosomes or maintained as episomal DNA and then transcriptionally activated or silenced. Here, we discuss the existing evidence on how the lentiviruses, adenoviruses, herpesviruses, hepadnaviruses and autonomous parvoviruses enter the nucleus.
Greber, U F, Fassati, A
openaire +4 more sources
Characterization of the murine cytomegalovirus genes encoding the major DNA binding protein and the ICP18.5 homolog [PDF]
, 1992 In several herpesviruses the genes for the major DNA binding protein (MDBP), a putative assembly protein, the glycoprotein B (gB), and the viral DNA polymerase (pol) coliocate.
Koszinowski, Ulrich H. +3 more
core +1 more source
Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]
, 2009 Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr +9 more
core +1 more source
Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs. [PDF]
, 2001 Protection against viral challenge with canine oral papillomavirus (COPV) was achieved by immunisation via particle-mediated DNA delivery (PMDD) of a plasmid encoding the COPV L1 gene to cutaneous and oral mucosal sites in beagle dogs.
Walcott, S. +7 more
core
Viral replication organelles: the highly complex and programmed replication machinery
Frontiers in MicrobiologyViral infections usually induce the rearrangement of cellular cytoskeletal proteins and organelle membrane structures, thus creating independent compartments [termed replication organelles (ROs)] to facilitate viral genome replication.
Hao Deng +7 more
doaj +1 more source
HIV-1 gene expression: lessons from provirus and non-integrated DNA
Retrovirology, 2004 Replication of HIV-1 involves a series of obligatory steps such as reverse transcription of the viral RNA genome into double-stranded DNA, and subsequent integration of the DNA into the human chromatin.
Wu Yuntao
doaj +1 more source
Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus. [PDF]
PLoS ONE, 2010 Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. The causal relationship of XMRV infection to human disease and the mechanism of pathogenicity have not ...
Sanggu Kim +5 more
doaj +1 more source