Results 41 to 50 of about 768,440 (168)

Determinazione quantitativa di HIV-1 DNA nel follow-up del paziente HIV-1 infetto: esperienza in un gruppo di soggetti HIV-1 infetti

Microbiologia Medica, 2006
Proviral HIV-1 DNA can represent an alternative viral marker to RNA viral load during the follow-up of HIV-1 infected individuals. Sequential blood samples of 12 patients under antiretroviral treatment from 1997 with two NRTIs, who refused to continue ...
Francesca Vitone, Davide Gibellini, Pasqua Schiavone, Isabella Bon, Maria Carla Re   +4 more
doaj   +1 more source

The role of unintegrated DNA in HIV infection

Retrovirology, 2011
Integration of the reverse transcribed viral genome into host chromatin is the hallmark of retroviral replication. Yet, during natural HIV infection, various unintegrated viral DNA forms exist in abundance. Though linear viral cDNA is the precursor to an
Wainberg Mark A, Sloan Richard D
doaj   +1 more source

PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation

Nature Communications, 2022
cGAS senses viral DNA and forms cytosolic cGAS-DNA granules to mediate anti-DNA viral signaling pathway. Here the authors show that PCBP2 interacts with cGAS and antagonizes condensation of cGAS-DNA granules, thus maintaining host immune homeostasis.
Haiyan Gu, Jing Yang, Jiayu Zhang, Ying Song, Yao Zhang, Pengfei Xu, Yuanxiang Zhu, Liangliang Wang, Pengfei Zhang, Lin Li, Dahua Chen, Qinmiao Sun   +11 more
doaj   +1 more source

Nuclear Import of Viral DNA Genomes [PDF]

Traffic, 2003
The genomes of many viruses traffic into the nucleus, where they are either integrated into host chromosomes or maintained as episomal DNA and then transcriptionally activated or silenced. Here, we discuss the existing evidence on how the lentiviruses, adenoviruses, herpesviruses, hepadnaviruses and autonomous parvoviruses enter the nucleus.
Greber, U F, Fassati, A
openaire   +4 more sources

Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues

mSphere, 2023
Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair.
Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug   +7 more
doaj   +1 more source

NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing.

PLoS Pathogens
Methylation of the DNA genome plays an important role in viral gene inactivation. However, the role of DNA methylation in human bocavirus (HBoV) remains unclear.
Shuangkang Qin, Honghe Chen, Chuchu Tian, Zhen Chen, Li Zuo, Xueyan Zhang, Haojie Hao, Fang Huang, Haibin Liu, Xiulian Sun, Wuxiang Guan   +10 more
doaj   +1 more source

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

iScience
Summary: To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription.
Dayana B. Hristova, Marisa Oliveira, Emma Wagner, Alan Melcher, Kevin J. Harrington, Alexandre Belot, Brian J. Ferguson   +6 more
doaj   +1 more source

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

Immunity & Ageing, 2019
Background T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood.
Yingjie Ji, Xindi Dang, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Dechao Cao, Sushant Khanal, Madison Schank, Xiao Y. Wu, Zheng D. Morrison, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao   +15 more
doaj   +1 more source

Preparation of Viral DNA from Nucleocapsids [PDF]

Journal of Visualized Experiments, 2011
Viruses are obligate cellular parasites, and thus the study of their DNA requires isolating viral material away from host cell contaminants and DNA. Several downstream applications require large quantities of pure viral DNA, which is provided by this protocol.
Moriah L, Szpara, Yolanda R, Tafuri, L W, Enquist   +2 more
openaire   +2 more sources

Viral oncoproteins target the DNA methyltransferases [PDF]

Oncogene, 2006
Small DNA tumour viruses have evolved a number of mechanisms to drive nondividing cells into S phase. Virally encoded oncoproteins such as adenovirus E1A and human papillomavirus (HPV) E7 can bind an array of cellular proteins to override proliferation arrest. The DNA methyltransferase Dnmt1 is the major mammalian enzyme responsible for maintaining CpG
Burgers, T, Blanchon, Loïc, Pradhan, S, de Launoit, Y, Kouzarides, T, Fuks, F, Burgers, W, Launoit, y De   +7 more
openaire   +4 more sources