Results 221 to 230 of about 219,109 (274)

Protocol for forming G-quadruplexes from double-stranded DNA during transcription. [PDF]

STAR Protoc
Zhang J, Gong J, Chen J, Chen H.
europepmc   +1 more source

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Advanced Science, EarlyView.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun   +13 more
wiley   +1 more source

Development of a loop-mediated isothermal amplification assay for detecting <i>Porphyromonas endodontalis</i>. [PDF]

J Conserv Dent Endod
Whitaker EJ, Shah LN, Miloradovic IR, Yesilsoy CJ, Badve SA.   +4 more
europepmc   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

The mutational landscape of Bacillus subtilis conditional hypermutators shows how proofreading skews DNA polymerase error rates. [PDF]

Nucleic Acids Res
Tanneur I, Dervyn E, Guérin C, Kon Kam King G, Jules M, Nicolas P.   +5 more
europepmc   +1 more source

DNA Molecular Computing with Weighted Signal Amplification for Cancer miRNA Biomarker Diagnostics

Advanced Science, EarlyView.
A molecular computing approach is presented with weighted signal amplification. Polymerase‐mediated strand displacement is employed to assign weights to target miRNAs, reflecting the miRNAs’ diagnostic values, followed by amplification of the weighted signals using localized DNA catalytic hairpin assembly.
Hongyang Zhao, Yumin Yan, Linghao Zhang, Xin Li, Lan Jia, Liang Ma, Xin Su   +6 more
wiley   +1 more source

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA. [PDF]

Commun Biol
Matsuda S, Nakayama M, Do Y, Ishiuchi T, Yagi M, Wanrooij S, Nakada K, Wei FY, Ichiyanagi K, Sasaki H, Kang D, Yasukawa T.   +11 more
europepmc   +1 more source

Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming

Advanced Science, EarlyView.
This study addresses the challenges of synthetic circular RNAimpurities that trigger immune responses and hinder efficacy. Key immunogenic byproducts are identified and develop a multi‐step purification process that produces ultra‐pure circRNA and enhances yields by over 10‐fold.
Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao   +7 more
wiley   +1 more source

Structural basis of error-prone DNA synthesis by DNA polymerase θ. [PDF]

Nat Commun
Li C, Maksoud LM, Gao Y.
europepmc   +1 more source

Neophytadiene, a Plant Specialized Metabolite, Mediates the Virus‐Vector‐Plant Tripartite Interactions

Advanced Science, EarlyView.
Tomato chlorosis virus (ToCV) infection induces production of neophytadiene, a volatile resulting from chlorophyll degradation that is highly attractive to whiteflies. OBP2, an odorant‐binding protein from insect vector B. tabaci, exhibits a strong binding affinity for neophytadiene.
Xiao‐bin Shi, Hao Yue, Yan Wei, Evan L. Preisser, Pei Wang, Jiao Du, Ji‐xing Xia, Kai‐long Li, Xin Yang, Jian‐bin Chen, Song‐bai Zhang, Zhan‐hong Zhang, Xu‐guo Zhou, De‐yong Zhang, Yong Liu   +14 more
wiley   +1 more source