Results 231 to 240 of about 235,447 (289)

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

Characterizing and Engineering a Succinate-Responsive Biosensor System in <i>Escherichia coli</i>. [PDF]

ACS Synth Biol
Zou Y, Qian Y, Parish C, Huddle L, Yan Y.   +4 more
europepmc   +1 more source

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

Polymerase-based DNA reactions for molecularly computing cancerous diagnostic valences of multiple miRNAs. [PDF]

J Nanobiotechnology
Yan Y, Zhao H, Xing L, Ouyang Y, Zhang L, Yang J, Qiu J, Qian Y, Ma L, Weng R, Su X.   +10 more
europepmc   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source

Live culture-based qPCR screening of Taq DNA polymerase variants for resistance to PCR inhibitors. [PDF]

Front Bioeng Biotechnol
Kermekchiev MB, Zhang Z, Barnes WM.
europepmc   +1 more source

Detection of gyrA gene mutations associated with ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus: analysis by polymerase chain reaction and automated direct DNA sequencing

, 1992
Joseph J. Goswitz, Karen Willard‐Gallo, C E Fasching, Lance R. Peterson   +3 more
openalex   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Precise mapping of single-stranded DNA breaks by sequence-templated erroneous DNA polymerase end-labelling. [PDF]

Nat Commun
Wenson L, Heldin J, Martin M, Erbilgin Y, Salman B, Sundqvist A, Schaal W, Sandbaumhüter FA, Jansson ET, Chen X, Davidsson A, Stenerlöw B, Espinoza JA, Lindström M, Lennartsson J, Spjuth O, Söderberg O.   +16 more
europepmc   +1 more source