Results 231 to 240 of about 219,109 (274)

DragonRNA: Generality of DNA-primed RNA-extension activities by DNA-directed RNA polymerases. [PDF]

Nucleic Acids Res
Greenwald E, Galls D, Park J, Jain N, Montgomery SB, Roy B, Yin YW, Fire AZ.   +7 more
europepmc   +1 more source

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

Harnessing microbial heterogeneity for improved biosynthesis fueled by synthetic biology. [PDF]

Synth Syst Biotechnol
Cao Y, Li J, Liu L, Du G, Liu Y.
europepmc   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

A robust strategy for overexpression of DNA polymerase from Thermus aquaticus using an IPTG-independent autoinduction system in a benchtop bioreactor. [PDF]

Sci Rep
Laksmi FA, Lischer K, Nugraha Y, Violando WA, Helbert, Nuryana I, Khasna FN, Nur N, Ramadhan KP, Tobing DAL, Hariyatun, Hidayat I.   +11 more
europepmc   +1 more source

Characterization of a new human apolipoprotein A-I Yame by direct sequencing of polymerase chain reaction-amplified DNA.

, 1991
Y Takada, Junichi Sasaki, Masahiko Seki, Shigenori Ogata, Yuichi Teranishi, K Arakawa   +5 more
openalex   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +8 more
wiley   +1 more source

Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations. [PDF]

ACS Synth Biol
Chia BS, Seah YFS, Wang B, Shen K, Srivastava D, Chew WL.   +5 more
europepmc   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Characterization and PCR Application of Family B DNA Polymerases from Thermococcus stetteri. [PDF]

Life (Basel)
Kuznetsova AA, Soloveva MA, Mikushina ES, Gavrilova AA, Bakman AS, Kuznetsov NA.   +5 more
europepmc   +1 more source