Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses
Nature, 1970 Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.
Spiegelman, S. +6 more
openaire +4 more sources
Error correction during DNA replication [PDF]
Physical Review E, VOL.86, 011913 (2012), 2011 DNA polymerase (DNAP) is a dual-purpose enzyme that plays two opposite roles in two different situations during DNA replication. It plays its normal role as a {\it polymerase} catalyzing the elongation of a new DNA molecule by adding a monomer. However, it can switch to the role of an {\it exonuclease} and shorten the same DNA by cleavage of the last ...
arxiv +1 more source
Engagement of Components of DNA-Break Repair Complex and NFκB in Hsp70A1A Transcription Upregulation by Heat Shock. [PDF]
PLoS ONE, 2017 An involvement of components of DNA-break repair (DBR) complex including DNA-dependent protein kinase (DNA-PK) and poly-ADP-ribose polymerase 1 (PARP-1) in transcription regulation in response to distinct cellular signalling has been revealed by ...
Joyita Hazra +4 more
doaj +1 more source
A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement [PDF]
, 2013 A significantly improved DNA polymerase fidelity assay, based on a gapped plasmid containing the lacZα reporter gene in a single-stranded region, is described.
Connolly, Bernard A +2 more
core +1 more source
Human placentas contain a specific inhibitor of RNA-directed DNA polymerase.
Proceedings of the National Academy of Sciences of the United States of America, 1981 Human placental extracts contain a specific inhibitor of mammalian retroviral RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) activity.
J. Nelson, J. Levy, J. Leong
semanticscholar +1 more source
What influences DNA replication rate in budding yeast? [PDF]
PLoS ONE, 2010 BACKGROUND: DNA replication begins at specific locations called replication origins, where helicase and polymerase act in concert to unwind and process the single DNA filaments. The sites of active DNA synthesis are called replication forks.
Thomas W Spiesser +3 more
doaj +1 more source
PLoS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences.
R. Erdmann, Colette L. Picard
semanticscholar +1 more source
miRNA‐29 regulates epidermal and mesenchymal functions in skin repair
FEBS Letters, EarlyView.miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan +10 more
wiley +1 more source
High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor [PDF]
, 2014 The human prostacyclin receptor (hIP receptor) is a seven-transmembrane G protein-coupled receptor (GPCR) that plays a critical role in vascular smooth muscle relaxation and platelet aggregation.
Anke Bill +57 more
core +13 more sources
Hamster leukemia virus: lack of endogenous DNA synthesis and unique structure of its DNA polymerase [PDF]
, 1974 Infectious hamster leukemia virus (HaLV) contains a DNA polymerase different from those of murine and avian viruses. No endogenous reaction directed by the 60 to 70S RNA of HaLV could be demonstrated in detergenttreated HaLV virions, nor could the ...
Baltimore, David +3 more
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