Results 101 to 110 of about 48,433 (280)

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Transcriptional Regulation by the Numbers 1: Models [PDF]

arXiv, 2004
The study of gene regulation and expression is often discussed in quantitative terms. In particular, the expression of genes is regularly characterized with respect to how much, how fast, when and where. Whether discussing the level of gene expression in a bacterium or its precise location within a developing embryo, the natural language for these ...
arxiv  

The developmental cell biology of Trypanosoma brucei [PDF]

, 2005
Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
core   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Salicylic acid collaborates with gene silencing to tomato defense against tomato yellow leaf curl virus (TYLCV) [PDF]

, 2018
Antiviral research in plants has been focused on RNA silencing (i.e. RNA interference), and several studies suggest that salicylic acid (SA)-mediated resistance is a key part of plant antiviral defense.
Crabbe, M. James C., Li, Yunzhou, Liang, Yan, Muhammad, Tayab, Wang, Yong, Zhang, Dalong   +5 more
core  

Recent Progress Toward the Templated Synthesis and Directed Evolution of Sequence-Defined Synthetic Polymers [PDF]

, 2009
Biological polymers such as nucleic acids and proteins are ubiquitous in living systems, but their ability to address problems beyond those found in nature is constrained by factors such as chemical or biological instability, limited building-block ...
Allart, Alvarez-Lorenzo, Anastasi, Anderson, Arnon, Bain, Bain, Barth, Bohler, Carrasco, Chaput, Chaput, Chaput, Chaput, Chen, Cochran, Crinelli, Das, David R. Liu, Dedkova, Dedkova, Dill, Dineva, Doi, Dueholm, Eckstein, Ellman, Englund, Eschenmoser, Forster, Frankel, Fujimoto, Galmarini, Gartner, Goodwin, Hartman, He, Hecht, Heckler, Hendrix, Hendrix, Henry, Henry, Hill, Hirao, Hocek, Holmberg, Horhota, Horhota, Horne, Hud, Hunter, Hwang, Ichida, Ichida, Jiang, Joyce, Jung, Kang, Kang, Kaur, Kawakami, Kawakami, Kay, Kempeneers, Kempeneers, King, King, Kirshenbaum, Kleiner, Kono, Kool, Kozlov, Kozlov, Kozlov, Kozlov, Krayevsky, Kubik, Kuwahara, Kuwahara, Lato, Lee, Leitzel, Letsinger, Letsinger, Levy-Nissenbaum, Lewis, Li, Li, Li, Liu, Lohrmann, Lohrmann, Lohrmann, Marx, Marx, McGall, McQuade, Miller, Murakami, Navani, Nelson, Nielsen, Ninio, Noren, O'Sullivan, Ohta, Ohta, Ohta, Orgel, Orgel, Patch, Patil, Phillips, Pochet, Poncin-Epaillard, Porter, Proske, Rosenbaum, Rothlisberger, Ryadnov, Schmidt, Schmidt, Schmidt, Schneider-Bernloehr, Sen, Shimizu, Shoyele, Spangler, Stormo, Subtelny, Sulston, Summerer, Summerer, Summers, Tan, Tomasz, Tuchscherer, Vasir, Vastmans, Vastmans, Vastmans, Veedu, Veedu, Veedu, Wang, Wang, Wang, White, White, Wilds, Wolfe, Wolfe, Woodley, Xie, Xie, Yevgeny Brudno, Yliperttula, Zhan, Zhang, Zhang   +160 more
core   +1 more source

BEAN and HABAS: Polyphyletic insertions in the DNA‐directed RNA polymerase

Protein Science
AbstractThe β and β′ subunits of the RNA polymerase (RNAP) are large proteins with complex multi‐domain architectures that include several insertional domains. Here, we analyze the domain organizations of RNAP‐β and RNAP‐β′ using sequence, experimentally determined structures and AlphaFold structure predictions.
Alvarez‐Carreño, Claudia, Huynh, Angela T., Petrov, Anton S., Orengo, Christine, Williams, Loren Dean   +4 more
openaire   +2 more sources