Results 101 to 110 of about 47,098 (282)

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

open access: yesAdvanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu   +9 more
wiley   +1 more source

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah   +9 more
wiley   +1 more source

Nuclear RNA Surveillance in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e: Trf4p-dependent Polyadenylation of Nascent Hypomethylated tRNA and an Aberrant Form of 5S rRNA [PDF]

open access: yes, 2006
1-Methyladenosine modification at position 58 of tRNA is catalyzed by a two-subunit methyltransferase composed of Trm6p and Trm61p in Saccharomyces cerevisiae.
Anderson, James T.   +2 more
core   +1 more source

Additional file 2: of Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

open access: yes, 2016
Materials and Methods. (DOCX 29Â kb)
Jungwon Han   +7 more
openaire   +1 more source

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

open access: yesAdvanced Healthcare Materials, EarlyView.
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale   +6 more
wiley   +1 more source

Directed evolution of novel polymerase activities: Mutation of a DNA polymerase into an efficient RNA polymerase [PDF]

open access: green, 2002
Gang Xia   +5 more
openalex   +1 more source

3D Bioprinting‐Assisted Engineering of Stem Cell‐Laden Hybrid Biopatches With Distinct Geometric Patterns Considering the Mechanical Characteristics of Regular and Irregular Connective Tissues

open access: yesAdvanced Healthcare Materials, EarlyView.
A hybrid biopatch platform integrating 3D printed polymeric patterns with stem cell‐laden collagen bioinks is developed to mimic the mechanical properties of connective tissues. By tailoring geometric architectures, the constructs replicate anisotropic or isotropic mechanics, enhancing tissue‐specific regeneration.
Minjun Ahn   +6 more
wiley   +1 more source

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