Results 121 to 130 of about 47,098 (282)

Interactions Between Active Matters and Endogenous Fields

Advanced Materials, EarlyView.
This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin, Qiaoxin Guan, Jiangqi Feng, Shuqin Chen, Leilei Xu, Jianguo Guan, Samuel Sánchez   +6 more
wiley   +1 more source

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Bringing Attomolar Detection to the Point‐of‐Care with Nanopatterned DNA Origami Nanoantennas

Advanced Materials, EarlyView.
Single DNA molecules are captured within the hotspots of DNA origami NanoAntennas arranged on a chip surface. Fluorescence is amplified, enabling direct detection on a point‐of‐care‐compatible imaging setup (visualized as bright signals against a dark background).
Renukka Yaadav, Kateryna Trofymchuk, Mihir Dass, Vivien Behrendt, Benedikt Hauer, Jan Schütz, Cindy Close, Michael Scheckenbach, Giovanni Ferrari, Leoni Mäurer, Sophia Sebina, Viktorija Glembockyte, Tim Liedl, Philip Tinnefeld   +13 more
wiley   +1 more source

Additional file 5: Figure S3. of Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians

, 2016
Reactivity of scFv clones to peptides. (A) YSATLRY, YSPTRFY, and three CTD peptides (one unphosphorylated and two phosphorylated peptides) were synthesized and conjugated to BSA. (B) Microtiter plates were coated with BSA-conjugated peptide and blocked with 3 % BSA in PBS.
Jungwon Han, Park, So-Hyun, Dong-Jo Kim, Hyori Kim, Yoon-Ho Choi, Jong-Hyuk Lee, Park, Sang, Junho Chung   +7 more
openaire   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses II. Directing Influence of RNA in the Reaction [PDF]

, 1972
Jonathan Leis, Jerard Hurwitz
openalex   +1 more source

3D‐Printed Unibody Microfluidic Devices for Organ‐on‐Chip Applications

Advanced Materials Technologies, EarlyView.
A practical approach is demonstrated to 3D printing unibody microfluidic Organ‐on‐Chip (OoC) devices using commercial resins and desktop DLP printers. The demonstrated functional devices support 2D monolayers, 3D spheroids, and barrier tissues. With optimised design and post‐processing techniques, leak‐free, biocompatible microchannels and membranes ...
Louis Jun Ye Ong, Surasak Kasetsirikul, Laura A. Milton, Xiaolei Nie, Andrea W. Eiken, James Chirnside, Lucy‐May Gillian Young, Gregory P. Nordin, Yi‐Chin Toh   +8 more
wiley   +1 more source

RNA-Dependent DNA Polymerase Activity of RNA Tumor Viruses I. Directing Influence of DNA in the Reaction [PDF]

, 1972
Jerard Hurwitz, Jonathan Leis
openalex   +1 more source

Edeine Inhibition and Resistance in Neurospora [PDF]

, 1974
A. Neuhäuser, A. Piekarowicz, B. Beetz, G. W. Beadle, H. J. Vogel, L. H. Hartwell, M. Hierowsky, M. L. Teles-Grilo, M. Pongratz, M. Wlodarczyk, N. H. Horowitz, R. S. Fisher, S. Jannsen, T. Obrig, T. P. Hettinger, W. Klingmüller, Z. Kurylo-Borowska, Z. Kurylo-Borowska, Z. Kurylo-Borowska   +18 more
core   +1 more source

Inhibiting the oligomerization of mycobacterial DNA-directed RNA polymerase (RNAP) using natural compound via in-silico techniques

Medicine in Novel Technology and Devices
Mycobacterium tuberculosis (Mtb) is responsible for the spread of tuberculosis (TB). The current study employed virtual screening of 2569 natural compounds against the DNA-directed RNA polymerase (RNAP) of Mtb to identify the possible binders that can inhibit its function.
openaire   +2 more sources