Results 131 to 140 of about 26,138 (240)

SAD-2 is required for meiotic silencing by unpaired DNA and perinuclear localization of SAD-1 RNA-directed RNA polymerase [PDF]

, 2006
Patrick Shiu, Denise Zickler, Namboori B. Raju, Gwenaël Ruprich‐Robert, Robert L. Metzenberg   +4 more
openalex   +1 more source

Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations

Advanced Science, EarlyView.
Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou, Qiyi Yi, Mengying Wu, Lijun Wu, Fanghua Li, Ting Wang, Po Bian   +6 more
wiley   +1 more source

Viruses in sanctuary chimpanzees across Africa

American Journal of Primatology, Volume 85, Issue 1, January 2023., 2023
Abstract Infectious disease is a major concern for both wild and captive primate populations. Primate sanctuaries in Africa provide critical protection to thousands of wild‐born, orphan primates confiscated from the bushmeat and pet trades. However, uncertainty about the infectious agents these individuals potentially harbor has important implications ...
Emily Dunay, Leah A. Owens, Christopher D. Dunn, Joshua Rukundo, Rebeca Atencia, Megan F. Cole, Averill Cantwell, Melissa Emery Thompson, Alexandra G. Rosati, Tony L. Goldberg   +9 more
wiley   +1 more source

Comparison of Commercially Available Thermostable DNA Polymerases with Reverse Transcriptase Activity in Coupled Reverse Transcription Polymerase Chain Reaction Assays. [PDF]

Methods Protoc
Smirnova EV, Blagodatskikh KA, Barsova EV, Varlamov DA, Kramarov VM, Ignatov KB.   +5 more
europepmc   +1 more source

Lactobacillus johnsonii Generates Cyclo(pro‐trp) and Promotes Intestinal Ca2+ Absorption to Alleviate CKD–SHPT

Advanced Science, EarlyView.
The mechanism map of how L.johnsonii generates cyclo(pro‐trp) to alleviate CKD–SHPT by promoting the expression of CaSR and TRPV4 in IECs, enhancing Ca2+ absorption, and negatively feedback inhibiting iPTH secretion. Abstract Patients with chronic kidney disease (CKD) are at a high risk of developing secondary hyperparathyroidism (SHPT), which may ...
Xiong Zeng, Lihua Sun, Huichao Xie, Shenhai Gong, Caibao Lu, Zhongwei Xu, Haidi Guan, Ben Han, Wei Wang, Zhengmin Zhang, Jieying Zhou, Shuai Wang, Yihui Chen, Weidong Xiao   +13 more
wiley   +1 more source

Measuring XNA polymerase fidelity in a hydrogel particle format. [PDF]

Nucleic Acids Res
Medina EL, Chaput JC.
europepmc   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, EarlyView.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Structural basis for intrinsic strand displacement activity of mitochondrial DNA polymerase. [PDF]

Nat Commun
Nayak AR, Sokolova V, Sillamaa S, Herbine K, Sedman J, Temiakov D.   +5 more
europepmc   +1 more source

ProteoSeeker: A Feature‐Rich Metagenomic Analysis Tool for Accessible and Comprehensive Metagenomic Exploration

Advanced Science, EarlyView.
ProteoSeeker is a new metagenomic analysis tool that accelerates protein discovery. By automating key steps, it reduces computational complexity and enables comprehensive dataset analysis, performing protein identification, screening based on user‐defined protein families, and taxonomic analysis.
Georgios Filis, Dimitra Bezantakou, Konstantinos Rigkos, Despina Noti, Pavlos Saridis, Dimitra Zarafeta, Georgios Skretas   +6 more
wiley   +1 more source

DNA polymerase ζ has robust reverse transcriptase activity relative to other cellular DNA polymerases. [PDF]

J Biol Chem
Mayle R, Holloman WK, O'Donnell ME.
europepmc   +1 more source