Results 141 to 150 of about 26,138 (240)

A Single Subunit from Avian Myeloblastosis Virus with Both RNA-Directed DNA Polymerase and Ribonuclease H Activity [PDF]

, 1973
Duane P. Grandgenett, Gary F. Gerard, Maurice Green   +2 more
openalex   +1 more source

Deep Learning‐Enhanced Hand‐Driven Microfluidic Chip for Multiplexed Nucleic Acid Detection Based on RPA/CRISPR

Advanced Science, EarlyView.
Efficient R‐CHIP HR‐HPV Screening System: The R‐CHIP system utilizes the RPA/CRISPR method, a hand‐driven centrifugal microfluidic device, a smartphone micro‐imaging system, and the ResNet‐18 deep‐learning algorithm to simplify the sample detection process, ensure accurate results, and reduce costs.
Tao Xu, Ying Zhang, Shunji Li, Chenxi Dai, Hongguo Wei, Dongjuan Chen, Yunjun Zhao, He Liu, Deliang Li, Peng Chen, Bi‐Feng Liu, Ye Tian   +11 more
wiley   +1 more source

Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations. [PDF]

ACS Synth Biol
Chia BS, Seah YFS, Wang B, Shen K, Srivastava D, Chew WL.   +5 more
europepmc   +1 more source

Relationship Between RNA-directed DNA Polymerase (Reverse Transcriptase) from Human Acute Leukemic Blood Cells and Primate Type-C Viruses [PDF]

, 1974
Robert E. Gallagher, George J. Todaro, R. Graham Smith, Dennis Livingston, Robert C. Gallo   +4 more
openalex   +1 more source

Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Advanced Science, EarlyView.
This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu, Boyang Cheng, Xingxing Zhu, Yeshuang Yuan, Siyu Wu, Yuanjie Zhang, Wen Shi, Zhiqian Chen, Xindang Chu, Jiayu Hu, Liwen Hua, Yiming Wang, Yanning Zhu, Yu Mu, Hanwen Sun, Chuanling Zhang, Qi Wang, Sulong Xiao, Lihe Zhang, Bo Zhang, Demin Zhou   +23 more
wiley   +1 more source

Next-Generation Sequencing Methods to Determine the Accuracy of Retroviral Reverse Transcriptases: Advantages and Limitations. [PDF]

Viruses
Martínez Del Río J, Menéndez-Arias L.
europepmc   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

The clinical potential of l-oligonucleotides: challenges and opportunities. [PDF]

Chem Sci
Shearer V, Yu CH, Han X, Sczepanski JT.
europepmc   +1 more source

RNA-Directed DNA Polymerase and Virus-Induced Leukemia in Mice [PDF]

, 1973
Alan M. Wu, Robert C. Ting, Robert C. Gallo   +2 more
openalex   +1 more source

Silicon Enhances Functional Mitochondrial Transfer to Improve Neurovascularization in Diabetic Bone Regeneration

Advanced Science, EarlyView.
These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma, Chen Lei, Tao Ye, Qian‐Qian Wan, Kai‐Yan Wang, Yi‐Na Zhu, Ling Li, Xu‐Fang Liu, Long‐Zhang Niu, Franklin R. Tay, Zhao Mu, Kai Jiao, Li‐Na Niu   +12 more
wiley   +1 more source