Results 231 to 240 of about 48,658 (277)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Recognition of unnatural base pairs by a eukaryotic DNA polymerase enables universal sequencing of an expanded genetic alphabet. [PDF]

Nucleic Acids Res
Luo H, Du Y, Sun L, Ye F, Ma J, Wang X, Wang Y, Chen T.   +7 more
europepmc   +1 more source

Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology. [PDF]

Molecules
Hamada S, Murayama K, Takezawa Y, Toyoda R, Kuzuya A.   +4 more
europepmc   +1 more source

Left-Handed Helices in DNA Nanotechnology. [PDF]

JACS Au
Selvam S, Mathivanan J, Chandrasekaran AR.   +2 more
europepmc   +1 more source

AI-driven discovery of antiretroviral drug bictegravir and etravirine as inhibitors against monkeypox and related poxviruses. [PDF]

Commun Biol
Wang Y, Ünlü A, Wang X, Çevrim E, Offermans DM, Flesseman MP, Zaeck LM, Wu L, Bijvelds MJC, Sam-Agudu NA, de Vries RD, Raymond K, Li P, Olğaç A, Wang W, Doğan T, Pan Q.   +16 more
europepmc   +1 more source

A small polymerase ribozyme that can synthesize itself and its complementary strand. [PDF]

Science
Gianni E, Kwok SLY, Wan CJK, Goeij K, Clifton BE, Colizzi ES, Attwater J, Holliger P.   +7 more
europepmc   +1 more source

The bacteriophage T4 replisome: a model system for understanding DNA replication mechanisms. [PDF]

EcoSal Plus
Spiering MM, Benkovic SJ.
europepmc   +1 more source

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The DNA-directed RNA polymerases of soybean

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Four cellular RNA polymerases have been partially purified from hypocotyls of soybean ( Glycine max ). Enzyme isolation from nuclear preparations indicate the DEAE polymerases I and II are localized within the nucleus. Inhibitor studies showed that DEAE polymerase II was preferentially inhibited by α-amanitin, DEAE peaks III and IV were ...
P A, Horgen, J L, Key
openaire   +3 more sources

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

Nature, 1970
Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.
Spiegelman, S., Burny, Arsène, Das, M R, Keydar, J., Schlom, J., Travnicek, M., Watson, Kenneth M.   +6 more
exaly   +4 more sources

Effect of granaticin on the activity of DNA-directed RNA polymerase fromStreptomyces granaticolor

Folia Microbiologica, 1989
DNA-directed RNA polymerase was isolated from wild-type and mutant (asporogenic and granaticin overproducing) Streptomyces granaticolor. The effect of granaticin on the enzyme activity was compared with that of standard transcription inhibitors, rifampicin and rifamycin SV and shown to be zero.
J, Smardová, J, Spízek, J, Stastná, M, Klégr   +3 more
openaire   +2 more sources