Results 61 to 70 of about 2,860,424 (274)

Novel platform for DNA alignment and studying DNA-protein interaction in realtime [PDF]

, 2011
Venkatesh A. Novel platform for DNA alignment and studying DNA-protein interaction in realtime. Bielefeld: Universität; 2011.Recreating DNA-protein interaction in vitro could unravel the relationship between their structure and function, which ...
Venkatesh, Alagarswamy
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Purification and partial characterization of an entomopoxvirus (DlEPV) from a parasitic wasp of tephritid fruit flies

Journal of Insect Science, 2002
An insect poxvirus [entomopoxvirus (EPV)] occurs in the poison gland apparatus of female Diachasmimorpha longicaudata , a parasitic wasp of the Caribbean fruit fly, Anastrepha suspensa and other tephritid fruit flies.
Pauline O. Lawrence
doaj  

Genetic and structural study of DNA-directed RNA polymerase II of Trypanosoma brucei, towards the designing of novel antiparasitic agents

PeerJ, 2017
Trypanosoma brucei brucei (TBB) belongs to the unicellular parasitic protozoa organisms, specifically to the Trypanosoma genus of the Trypanosomatidae class.
Papageorgiou, L., Megalooikonomou, V., Vlachakis, D.   +2 more
openaire   +5 more sources

Fidelity in Archaeal Information Processing [PDF]

, 2010
A key element during the flow of genetic information in living systems is fidelity. The accuracy of DNA replication influences the genome size as well as the rate of genome evolution.
Stan J. J. Brouns, Brouns, S.J.J., Fabian Blombach, Koning, B., de, van der Oost, J., de Koning, B., Blombach, F., Oost, J., van der, Bart de Koning, John van der Oost   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Expression, crystallization and preliminary X-ray crystallographic analysis of DNA-directed RNA polymerase subunit L fromThermococcus onnurineusNA1 [PDF]

Acta Crystallographica Section F Structural Biology Communications, 2014
RNA polymerase (RNAP) plays a crucial role in gene expression in all organisms. It is a multiprotein complex that produces primary transcript RNA. Generally, the basal transcription apparatus in archaea is simpler than the eukaryotic RNA polymerase II counterpart.
Thien Hoang, Ho, Myoung Ki, Hong, Ho Phuong Thuy, Ngo, Lin Woo, Kang   +3 more
openaire   +2 more sources

The molecular basis of nucleotide recognition for T7 DNA polymerase [PDF]

, 2008
textDNA replication demands extraordinary specificity and efficiency of catalysis from a DNA polymerase. Previous studies on several DNA polymerases suggested that a rate-limiting conformational change preceding chemistry accounts for the high ...
Jin, Zhinan, 1972-
core  

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]

, 2011
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Geacintov, Nicholas E., Tateishi, Satoshi, D'Andrea Alan, Jungmin Kim, Reißner Thomas, Goren, Zohar, Peter H L Krijger, Zvi Livneh, Hendel Ayal, Langerak, Petra, Alan D'Andrea, Kyungjae Myung, Petra Langerak, Nicholas E. Geacintov, Zohar Goren, Satoshi Tateishi, Myung Kyungjae, Goren Zohar, Kim, Jungmin, Jacobs, Heinz, Reißner, Thomas, Nicholas E Geacintov, Jacobs Heinz, Hendel, Ayal, Lee Kyoo-young, Livneh Zvi, Kyoo-young Lee, Diamant, Noam, Geacintov Nicholas E., Krijger, Peter H. L., Peter H. L. Krijger, Noam Diamant, Kim Jungmin, Carell Thomas, Heinz Jacobs, Carell, Thomas, D'Andrea, Alan, Ayal Hendel, Thomas Reissner, Tateishi Satoshi, Myung, Kyungjae, D'Andrea, Alan, Krijger Peter H. L., Lee, Kyoo-young, Thomas Carell, Diamant Noam, Livneh, Zvi, Langerak Petra   +47 more
core   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source