Results 41 to 50 of about 48,658 (277)

TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle [PDF]

, 2016
Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors.
Gietl, Andreas, Grohmann, Dina, Schulz, Sarah, Smollett, Katherine, Tinnefeld, Philip, Werner, Finn   +5 more
core   +1 more source

Putting the genome on the map [PDF]

, 1998
The maps of our everyday lives are much more than just linear lists of place names. Instead, their colours, symbols, contours and grid lines seek to describe different types of landscape, and to depict the spatial relationships between structural and ...
Andrulis, Baumgartner, Belmont, Bickmore, Blencowe, Boddy, Boy de la Tour, Brett, Bridger, Bridger, Brown, Buchenau, Capco, Carter, Clemson, Craig, Craig, Craig, Cremer, Cross, Csink, Dernburg, Dietzel, Dobie, Eils, Ferguson, Ferreira, Festenstein, Foisner, Fox, Gerdes, Gotta, Heck, Hernandez-Verdun, Hozak, Imai, Jackson, Jackson, Jeppesen, Kill, Krystosek, Kurz, LaSalle, Lawlis, Leitch, Li, Linares-Cruz, Maillet, Marshall, McQueen, Milot, Mortillaro, Nagele, O'Keefe, Paillsson, Paulson, Pombo, Pyrpasopoulou, Razin, Razin, Robinett, Saccone, Sachs, Saitoh, Satijn, Shelby, Taniura, Vourc'h, Weitspolthammer, Ye, Yokota, Zink, Zirbel   +72 more
core   +1 more source

Real-time kinetics and high-resolution melt curves in single-molecule digital LAMP to differentiate and study specific and non-specific amplification [PDF]

, 2020
Isothermal amplification assays, such as loop-mediated isothermal amplification (LAMP), show great utility for the development of rapid diagnostics for infectious diseases because they have high sensitivity, pathogen-specificity and potential for ...
Barlow, Jacob T., Ismagilov, Rustem F., Jue, Erik, Rolando, Justin C.   +3 more
core   +2 more sources

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [PDF]

Biochemical Journal, 1997
A natural compound from the Red Sea sponge Ircinia sp., 2-hexaprenylhydroquinone (HPH), has been shown to be a general inhibitor of retroviral reverse transcriptases (from HIV-1, HIV-2 and murine leukaemia virus) as well as of cellular DNA polymerases (Escherichia coli DNA polymerase I, and DNA polymerases α and β).
S, Loya, A, Rudi, Y, Kashman, A, Hizi
openaire   +2 more sources

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources

DNA-directed termination of mammalian RNA polymerase II

Genes & Development
ABSTRACT The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII from the DNA template.
Davidson, Lee, Rouvière, Jérôme O.; id_orcid 0000-0002-0269-1971, Sousa-Luís, Rui, Nojima, Takayuki, Proudfoot, Nicholas J., Jensen, Torben Heick; id_orcid 0000-0001-5127-1239, West, Steven   +6 more
openaire   +3 more sources

Isolation and characterization of monoclonal antibodies directed against two subunits of rabbit poxvirus-associated, DNA-directed RNA polymerase [PDF]

Journal of Virology, 1985
A library of monoclonal antibodies directed against individual proteins of the rabbit poxvirus (RPV) virion within a complex immunogenic mixture has been generated through the use of in vivo and in vitro immunization regimens. The relative efficacies of the two procedures were compared.
D K, Morrison, J K, Carter, R W, Moyer
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Entropy involved in fidelity of DNA replication [PDF]

, 2012
Information has an entropic character which can be analyzed within the Statistical Theory in molecular systems. R. Landauer and C.H. Bennett showed that a logical copy can be carried out in the limit of no dissipation if the computation is performed ...
Gonzalo G. de Polavieja, J. Ricardo Arias-Gonzalez   +1 more
core   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source