Results 31 to 40 of about 3,029,744 (275)

Simultaneous Disruption of Two DNA Polymerases, Pol eta and Pol zeta, in Avian DT40 Cells Unmasks the Role of Pol eta in Cellular Response to Various DNA Lesions [PDF]

, 2010
Replicative DNA polymerases are frequently stalled by DNA lesions. The resulting replication blockage is released by homologous recombination (HR) and translesion DNA synthesis (TLS). TLS employs specialized TLS polymerases to bypass DNA lesions.
Sonoda, E, Dávid Szüts, Hirota Kouji, Takuo Kawamoto, Shunichi Takeda, Motegi, Akira, Motegi Akira, Fumio Hanaoka, Kawamoto Takuo, Julian E. Sale, Kawamoto, Takuo, Iwai, Shigenori, Julian E Sale, Sale Julian E., Sonoda Eiichiro, Masutani Chikahide, Shigenori Iwai, Alan Lehmann, Masutani, C, Takeda, Shunichi, Iwai Shigenori, Lehmann, Alan, Chikahide Masutani, Szüts, Dávid, Iwai, S, Eiichiro Sonoda, Motegi, A, Kawamoto, T, Masutani, Chikahide, Kouji Hirota, Hanaoka Fumio, Szüts, D, Takeda Shunichi, Hirota, Kouji, Sale, Julian E, Szüts Dávid, Hanaoka, Fumio, Lehmann Alan, Takeda, S, Hirota, K, Hanaoka, F, Sale, JE, Akira Motegi, Sonoda, Eiichiro, Lehmann, A   +44 more
core   +1 more source

Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana

BMC Plant Biology, 2012
Background In plants, transposons and non-protein-coding repeats are epigenetically silenced by CG and non-CG methylation. This pattern of methylation is mediated in part by small RNAs and two specialized RNA polymerases, termed Pol IV and Pol V, in a ...
You Wanhui, Tyczewska Agata, Spencer Matthew, Daxinger Lucia, Schmid Marc W, Grossniklaus Ueli, Simon Stacey A, Meyers Blake C, Matzke Antonius JM, Matzke Marjori   +9 more
doaj   +1 more source

Subunit Compositions of Arabidopsis DNA-Dependent RNA Polymerases and the Roles of the Plant-Specific RNA Polymerases IV and V in Gene Silencing [PDF]

, 2009
In addition to RNA polymerases I, II and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, abbreviated as Pol IV and Pol V, that play non-redundant roles in siRNA-directed DNA methylation ...
Ream, Thomas
core   +1 more source

Mode of inhibition of HIV reverse transcriptase by 2-hexaprenylhydroquinone, a novel general inhibitor of RNA-and DNA-directed DNA polymerases [PDF]

Biochemical Journal, 1997
A natural compound from the Red Sea sponge Ircinia sp., 2-hexaprenylhydroquinone (HPH), has been shown to be a general inhibitor of retroviral reverse transcriptases (from HIV-1, HIV-2 and murine leukaemia virus) as well as of cellular DNA polymerases (Escherichia coli DNA polymerase I, and DNA polymerases α and β).
S, Loya, A, Rudi, Y, Kashman, A, Hizi
openaire   +2 more sources

Analyses of the archaeal transcription cycle reveal a mosaic of eukaryotic RNA polymerase II and III-like features [PDF]

, 2009
Novel mechanistic properties of the archaeal transcription system that reveal similarities especially to the eukaryotic RNA polymerase II and III systems were presented in thesis.
Spitalny, Patrizia
core   +1 more source

DNA-directed termination of mammalian RNA polymerase II

Genes & Development
ABSTRACT The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination involves polyadenylation site-directed cleavage of the nascent RNA. The RNAPII-associated cleavage product is then degraded by XRN2, dislodging RNAPII from the DNA template.
Davidson, Lee, Rouvière, Jérôme O.; id_orcid 0000-0002-0269-1971, Sousa-Luís, Rui, Nojima, Takayuki, Proudfoot, Nicholas J., Jensen, Torben Heick; id_orcid 0000-0001-5127-1239, West, Steven   +6 more
openaire   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

Nature, 1970
Several RNA tumour viruses contain an enzyme that synthesizes a DNA–RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.
Spiegelman, S., Burny, Arsène, Das, M R, Keydar, J., Schlom, J., Travnicek, M., Watson, Kenneth M.   +6 more
openaire   +3 more sources

Isolation and characterization of monoclonal antibodies directed against two subunits of rabbit poxvirus-associated, DNA-directed RNA polymerase [PDF]

Journal of Virology, 1985
A library of monoclonal antibodies directed against individual proteins of the rabbit poxvirus (RPV) virion within a complex immunogenic mixture has been generated through the use of in vivo and in vitro immunization regimens. The relative efficacies of the two procedures were compared.
D K, Morrison, J K, Carter, R W, Moyer
openaire   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source