Results 21 to 30 of about 48,658 (277)

Ribonucleolytic resection is required for repair of strand displaced nonhomologous end-joining intermediates [PDF]

, 2013
Nonhomologous end-joining (NHEJ) pathways repair DNA double-strand breaks (DSBs) in eukaryotes and many prokaryotes, although it is not reported to operate in the third domain of life, archaea. Here, we describe a complete NHEJ complex, consisting of DNA
Bartlett, Edward, Brissett, Nigel C, Doherty, Aidan J   +2 more
core   +1 more source

In Silico Analysis of Honey Bee Peptides as Potential Inhibitors of Capripoxvirus DNA-Directed RNA Polymerase

Animals, 2023
The genus Capripoxvirus belongs to the Poxviridae family. The sheeppox, goatpox, and lumpy skin disease viruses are three species of this genus with 96% identity in their genomes. These are financially devastating viral infections among cattle, which cause a reduction in animal products and lead to a loss in livestock industries.
Ghulam Mustafa, Hafiza Salaha Mahrosh, Mahwish Salman, Muhammad Ali, Rawaba Arif, Sibtain Ahmed, Hossam Ebaid   +6 more
openaire   +3 more sources

Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]

, 2017
Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a B400 kDa five-subunit catalytic core.
Forrest, David, James, Katherine, Yuzenkova, Yulia, Zenkin, Nikolay   +3 more
core   +2 more sources

Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]

, 2015
Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty, Benjamin A. Keen, Bianchi, Bouché, Collins, Crute, Kaguni, Klinedinst, Klinedinst, Koonin, Marsden, Moss, Nigel C. Brissett, Rowen, Scherzinger, Sherman, Takechi, Thomas A. Guilliam   +17 more
core   +1 more source

DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

Nature, 1970
Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.
Spiegelman, S., Burny, Arsène, Das, M R, Keydar, J., Schlom, J., Travnicek, M., Watson, Kenneth M.   +6 more
openaire   +3 more sources

Inhibition of Ebola Virus by Anti-Ebola miRNAs in silico

Journal of Infection in Developing Countries, 2016
Introduction: MicroRNAs (miRNAs) are small, noncoding RNA molecules that regulate transcriptional and posttranscriptional gene regulation of the organisms. miRNA provides immune defense when the body is faced with challenges intracellular agents.
Zhabiz Golkar, Roshan Battaria, Donald G Pace, Omar Bagasra   +3 more
doaj   +1 more source

Translesion synthesis DNA polymerase η exhibits a specific RNA extension activity and a transcription-associated function [PDF]

, 2017
We thank Andres Aguilera for providing the pCYC-LacZ plasmid for the GLRO experiments, and Szilvia Minorits for technical assistance. This work was also supported by grants from the National Research, Development and Innovation Office: GINOP-2.3.2-15 ...
Balint, Eva, Frittmann, Orsolya, Gali, Vamsi K, Serbyn, Nataliia, Stutz, Francoise, Unk, Ildiko   +5 more
core   +3 more sources

Isolation and physical properties of the DNA‐directed RNA polymerase from Thermus thermophilus HB8 [PDF]

European Journal of Biochemistry, 1990
The DNA‐directed RNA polymerase from the extremely thermophilic eubacterium Thermus thermophilus HB8 was purified employing a new and rapid method. The subunit pattern of the enzyme, analyzed by SDS gel electrophoresis, was interpreted as: 140 kDa and 170 kDa for β and β′, 40 kDa for α and 92 kDa for ó.
S, Wnendt, R K, Hartmann, N, Ulbrich, V A, Erdmann   +3 more
openaire   +2 more sources

Antibodies to the DNA-directed RNA polymerase II subunit RPB1 occur with highest frequency in centenarians [PDF]

Immunity & Ageing, 2016
Recently, phage display technology has made it possible to define the circulating repertoire of humoral immunity. This study was designed to define the circulating antibodies specific to centenarians.We used a phage-displayed combinatorial peptide library to screen for peptides (YSATLRY and YSPTLFY) that preferentially react with the IgG fraction of ...
Han, Jungwon, Park, So-Hyun, Kim, Dong-Jo, Kim, Hyori, Choi, Yoon-Ho, Lee, Jong-Hyuk, Park, Sang Chul, Chung, Junho   +7 more
openaire   +3 more sources

Investigation of Multi-Subunit Mycobacterium tuberculosis DNA-Directed RNA Polymerase and Its Rifampicin Resistant Mutants

International Journal of Molecular Sciences, 2023
Emerging Mycobacterium tuberculosis (Mtb) resistant strains have continued to limit the efficacies of existing antitubercular therapies. More specifically, mutations in the RNA replicative machinery of Mtb, RNA polymerase (RNAP), have been widely linked to rifampicin (RIF) resistance, which has led to therapeutic failures in many clinical cases ...
Mokgerwa Zacharia Monama, Fisayo Olotu, Özlem Tastan Bishop   +2 more
openaire   +2 more sources