Results 191 to 200 of about 8,837,195 (335)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Rapid isolation of high molecular weight plant DNA.

Nucleic Acids Research, 1980
M. Murray, W. F. Thompson
semanticscholar   +1 more source

Catalytic hairpin DNA assembly-based chemiluminescent assay for the detection of short SARS-CoV-2 target cDNA

, 2021
Ji Yoon, Ji Yun Jeong, Cheol Am Hong
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Association Between Abnormal DNA Methylation and Altered Transcriptome in Muscle Five Years After Critical Illness. [PDF]

J Cachexia Sarcopenia Muscle
Uzun Ayar C, Güiza F, Derese I, Van den Berghe G, Vanhorebeek I.   +4 more
europepmc   +1 more source

Structural basis for enzymatic excision of N1‐methyladenine and N3‐methylcytosine from DNA [PDF]

, 2007
Ingar Leiros, Marivi P Nabong, Kristin Grøsvik, Jeanette Ringvoll, Gyri T. Haugland, Lene Uldal, Karen Reite, Inger K. Olsbu, Ingeborg Knævelsrud, Elin Moe, Ole A. Andersen, Nils-Kåre Birkeland, Peter Ruoff, Arne Klungland, Svein Bjelland   +14 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

RA-risk synovium exhibits DNA damage coupled with impaired DNA repair in fibroblasts. [PDF]

RMD Open
O'Byrne AM, de Jong TA, Semmelink JF, Krawczyk PM, Hoebe RA, van de Sande M, van Baarsen L.   +6 more
europepmc   +1 more source

Tandem repeats finder: a program to analyze DNA sequences.

Nucleic Acids Research, 1999
Gary Benson
semanticscholar   +1 more source

Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences

, 2018
Annarosaria De Vito, Massimo Lazzaro, Ilaria Palmisano, Davide Cittaro, Michela Riba, Dejan Lazarević, Makoto Bannai, Davide Gabellini, Maria Vittoria Schiaffino   +8 more
openalex   +2 more sources