Results 191 to 200 of about 6,548,876 (337)

Sensitized photodimerization of thymine in DNA.

, 1967
Angelo A. Lamola, T. Yamane
openalex   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

DNA CONTENT OF HUMAN SPERMATOZOA AFTER STORAGE AT LOW TEMPERATURES [PDF]

, 1968
D. R. ACKERMAN, U. A. Sod-Moriah
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

GENETIC RECOMBINATION IN DNA-INDUCED TRANSFORMATION OF PNEUMOCOCCUS. I. THE PROBLEM OF RELATIVE EFFICIENCY OF TRANSFORMING FACTORS

, 1965
Harriett Ephrussi-Taylor, A M Sicard, Robert Kamen   +2 more
openalex   +2 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Synthetic Lethal Combinations of DNA Repair Inhibitors and Genotoxic Agents to Target High-Risk Diffuse Large B Cell Lymphoma. [PDF]

Hematol Oncol
Ovejero S, Devin J, Alibert L, Soun C, Lin YL, Dutrieux L, Abouladze M, Garcia de Paco E, Karmous Gadacha O, Constantinou A, Cartron G, Herbaux C, Elemento O, Pasero P, Roulland S, Moreaux J, Bret C.   +16 more
europepmc   +1 more source

THE GENETIC PROPERTIES OF DNA TRANSFERRED FROM ULTRAVIOLET-IRRADIATED Hfr CELLS OF ESCHERICHIA COLI K-12 DURING MATING [PDF]

, 1968
Brian M. Wilkins, Paul Howard-Flanders
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

bFuzzy logic-based approach for porcine DNA determination in meat products. [PDF]

NPJ Sci Food
Rajesh Mavani N, Mohd Ali J, Abd Rahman N, Hashim H, Abdul Mutalib S, Hussain MA.   +5 more
europepmc   +1 more source