Results 231 to 240 of about 6,778,475 (339)

Promising Results With NAD Supplementation in Rare Diseases With Premature Aging and DNA Damage. [PDF]

Aging Cell
Bohr VA.
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

P745: High-fidelity whole genome sequencing of FFPE tumor-derived nucleic acids stored at ambient temperature

Genetics in Medicine Open
Farnoosh Abbas-Aghababazadeh, Lee Organick, Michael Blas, Benjamin Haibe-Kains, James Banal, Celeste Yu, Philippe Bedard, Heather Williams   +7 more
doaj   +1 more source

Comprehensive Review on DNA Hydrogels and DNA Origami-Enabled Wearable and Implantable Biosensors. [PDF]

Biosensors (Basel)
Li M, Bae J.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

P845: HemaSure-OMXP: A non-toxic venous whole blood collection device enabling the 14-day room temperature stabilization of cell-free DNA

Genetics in Medicine Open
Andrew Wood, Veronika Rapoport, Ying Wang   +2 more
doaj   +1 more source

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways. [PDF]

Nucleic Acids Res
Norris JL, Rogers LO, Young G, Pytko KG, Dannenberg RL, Perreault S, Kaushik V, Antony E, Hedglin M.   +8 more
europepmc   +1 more source

Junk DNA: "DNA zabor" ala "DNA txatar"?

, 2013
Funtzio ezagunik edo argirik ez duen genomaren zatia DNA zabor bezala ezagutzen da. DNA zaborra eratzen duten osagaiak gehiago ikertzen goazen heinean, osagai hauek genometan izan dezaketen garrantzia ere azaleratzen doa. Era berean, hain garrantzia handia egozten ez dioten aurkikuntzak ere egin dira.
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source