Results 231 to 240 of about 8,718,410 (331)

The influence of base-pair changes on DNA denaturation profiles [PDF]

, 1988
I. V. Razlutsky, Luda S. Shlyakhtenko, Yu. L. Lyubchenko   +2 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Approaching single-molecule assembly-free readout from medium-length encoded DNA. [PDF]

Nat Commun
Chen W, Qin R, Guo Q, Guo J, Ge Q, Yuan Y.   +5 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

P745: High-fidelity whole genome sequencing of FFPE tumor-derived nucleic acids stored at ambient temperature

Genetics in Medicine Open
Farnoosh Abbas-Aghababazadeh, Lee Organick, Michael Blas, Benjamin Haibe-Kains, James Banal, Celeste Yu, Philippe Bedard, Heather Williams   +7 more
doaj   +1 more source

A novel fluorescent nanoprobe based on DNA silver nanoclusters for the detection of DEQ. [PDF]

RSC Adv
Li Y, Liu X, Zhang B, Gao F.
europepmc   +1 more source

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Science, 2013
Lijun Sun, Jiaxi Wu, Fenghe Du, Xiang Chen, Zhijian J. Chen   +4 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

The SMC Hinge is a Selective Gate for Obstacle Bypass. [PDF]

Nat Commun
Liu HW, Roisné-Hamelin F, Taschner M, Collier J, Srinivasan M, Gruber S.   +5 more
europepmc   +1 more source