Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
NLRP10 engages oxidized DNA through a Schiff-base mechanism and dissociates from NLRP3 upon inflammasome activation. [PDF]
Commun BiolCabral JE +8 more
europepmc +1 more source
Biophysics of protein–DNA interactions and chromosome organization
, 2014 John F. Marko
openalex +2 more sources
DNA fingerprints applied to gene introgression in breeding programs. [PDF]
, 1990 J. Hillel +6 more
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Structure of defense against restriction proteins DarA and Hdf in phage P1 reveals a new molecular mechanism during phage assembly, infection and DNA ejection. [PDF]
PLoS PathogZheng J +6 more
europepmc +1 more source
DNA targeting specificity of RNA-guided Cas9 nucleases
Nature Biotechnology, 2013 P. Hsu +13 more
semanticscholar +1 more source
Biphasic amplification of very dilute DNA samples via ‘booster‘ PCR [PDF]
, 1989 Gualberto Ruaño +2 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Structure of Bacillus subtilis Ku-mediated DNA synaptic complex. [PDF]
Nucleic Acids ResKim WJ, Kim J, Jo M, Kim Y, Kim MS.
europepmc +1 more source