Results 251 to 260 of about 8,837,195 (335)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Efficient recovery and DNA extraction for algae-associated microbial communities. [PDF]

Front Plant Sci
Chevokina E, Sibiryakina D, Sobolev A, Slonova D, Demkina A, Yurikova D, Galivondzhyan A, Konovalova O, Sutormin D, Isaev A.   +9 more
europepmc   +1 more source

TAR DNA-Binding Protein 43 and Disrupted in Schizophrenia 1 Coaggregation Disrupts Dendritic Local Translation and Mental Function in Frontotemporal Lobar Degeneration

, 2018
Ryo Endo, Noriko Takashima, Yoko Nekooki-Machida, Yusuke Komi, Kelvin K. Hui, Masaki Takao, Hiroyasu Akatsu, Shigeo Murayama, Akira Sawa, Motomasa Tanaka   +9 more
openalex   +2 more sources

Nuclear DNA Amounts in Pteridophytes [PDF]

, 2001
M. D. Bennett
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

P845: HemaSure-OMXP: A non-toxic venous whole blood collection device enabling the 14-day room temperature stabilization of cell-free DNA

Genetics in Medicine Open
Andrew Wood, Veronika Rapoport, Ying Wang   +2 more
doaj   +1 more source

Swift SNPs: Evaluating Rapid DNA Extraction Methods for Scalable Genotyping in Aquaculture. [PDF]

Mar Biotechnol (NY)
Rhodes E, Jerry D, Jones DB, Goldsbury J, Vu N.   +4 more
europepmc   +1 more source

The DNA-damage response in human biology and disease

Nature, 2009
S. Jackson, J. Bartek
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside. [PDF]

Transl Stroke Res
Xie Z, Luo Y, Han Z.
europepmc   +1 more source