Results 251 to 260 of about 6,548,876 (337)

A new twist on lactate signaling: alanyl-tRNA synthetases 1 and 2 as metabolic sensors and lactyltransferases. [PDF]

Mol Biomed
Xiao T, Wang F, Long X.
europepmc   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Role of Ionizing Radiation in Shaping the Complex Multi-Layered Epigenome. [PDF]

Epigenomes
Rübe CE, Al-Razaq MAA, Meier C, Hecht M, Rübe C.   +4 more
europepmc   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

NIPBL and STAG1 enable loop extrusion by providing differential DNA-cohesin affinity. [PDF]

Proc Natl Acad Sci U S A
van Wee R, Asor R, Li Y, Drechsel D, Popova M, Litos G, Davidson IF, Peters JM, Kukura P.   +8 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Navigating uncertainty in museum workflows: genomic data mining and curation of the Diptera collections hosted at RMCA. [PDF]

Biodivers Data J
Esselens L, Addison P, Bakengesa J, Bota L, Canhanga L, Cugala D, Daniel B, De Meyer M, Delatte H, Herpers JM, Jordaens K, Kabota S, Kudra A, Majubwa R, Manrakhan A, Mussumbe M, Mwatawala M, Theeten F, Van den Spiegel D, Vanbergen S, Vangestel C, Virgilio M.   +21 more
europepmc   +1 more source

DNA, RNA融解曲線の自記記録装置

, 1966
Sadato Yabuki, Akiyoshi Wada
openalex   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Automated Fluorescent DNA Sequencing by a Simplified Solid-Phase Chemical Sequencing Method

BioTechniques, 1997
Reiko Ohara, Ayako Tanaka, Osamu Ohara
doaj   +1 more source