Results 81 to 90 of about 6,548,876 (337)
DNA Damage, Mutagenesis, and DNA Repair [PDF]
Journal of Nucleic Acids, 2010 This special issue of the Journal of Nucleic Acids is dedicated to DNA damage and two important biological consequences provoked by such damage: lesion repair and lesion-induced mutagenesis. These phenomena have attracted broad interest among a large community of scientists that cross disciplines from mathematics, physics, chemistry, and biology to ...
Suse Broyde +3 more
openaire +4 more sources
Biotechnology for Biofuels, 2019 Background Bio-based production of organic acids promises to be an attractive alternative for the chemicals industry to substitute petrochemicals as building-block chemicals.
Abeer H. Hossain +6 more
doaj +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Microelectronics Journal, 2008 Submitted on behalf of TIMA Editions (http://irevues.inist.fr/tima-editions)
Hamdi M., Ferreira A.
openaire +4 more sources
DNA loops and semicatenated DNA junctions [PDF]
BMC Biochemistry, 2000 Alternative DNA conformations are of particular interest as potential signals to mark important sites on the genome. The structural variability of CA microsatellites is particularly pronounced; these are repetitive poly(CA). poly(TG) DNA sequences spread in all eukaryotic genomes as tracts of up to 60 base pairs long.
Claire Gaillard, François Strauss
openaire +3 more sources
One generic synonym and one new species of Phlaeothripidae from India (Thysanoptera)
ZooKeys, 2018 Haplothrips shivendraii Tyagi & Kumar, sp. n. is described from Rajasthan state of India. The monobasic Austro-oriental genus Dyothrips Kudô is formally synonymised with Haplothrips.
Kaomud Tyagi +3 more
doaj +3 more sources
Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing [PDF]
, 2017 Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than conventional methods, less GC bias, and the ability to read DNA base modifications.
Henley, Robert Y. +4 more
core +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Development of Phosphorothioate DNA and DNA Thioaptamers [PDF]
Biomedicines, 2017 Nucleic acid aptamers are short RNA- or DNA-based affinity reagents typically selected from combinatorial libraries to bind to a specific target such as a protein, a small molecule, whole cells or even animals. Aptamers have utility in the development of diagnostic, imaging and therapeutic applications due to their size, physico-chemical nature and ...
David Volk, Ganesh Lokesh
openaire +4 more sources
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source