Results 61 to 70 of about 4,554,738 (310)

Itaconic acid degradation in Aspergillus niger: the role of unexpected bioconversion pathways

Fungal Biology and Biotechnology, 2019
Background Itaconic acid (IA), a C5-dicarboxylic acid, has previously been identified as one of the top twelve biochemicals that can be produced by biotechnological means.
Abeer H. Hossain, Alexander Ter Beek, Peter J. Punt   +2 more
doaj   +1 more source

Finding Needle in the Haystack: “Kasur’s Bogeyman” Brought to Justice by Geographic Profiling and Mass DNA Screening

Brazilian Journal of Forensic Sciences, Medical Law and Bioethics, 2021
This article describes the application of the concept of geographic profiling in hunting a serial child rapist in Kasur, Pakistan. It also discusses, how DNA became the prime witness against the serial rapist in the court of law.
Muhammad Ahsan Butt, Talha Bin Rahat, Nasir Siddique, Madiha Shad, Sajjad Ahmad, Qazi Laeeque Ahmed, Muhammad Amjad, Mohammad Ashraf Tahir   +7 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics

Nature Communications
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell receptor signaling and as such is an attractive target for cancer immunotherapy.
Avantika S. Chitre, Ping Wu, Benjamin T. Walters, Xiangdan Wang, Alexandre Bouyssou, Xiangnan Du, Isabelle Lehoux, Rina Fong, Alisa Arata, Joyce Chan, Die Wang, Yvonne Franke, Jane L. Grogan, Ira Mellman, Laetitia Comps-Agrar, Weiru Wang   +15 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Tomato protoplast DNA transformation: physical linkage and recombination of exogenous DNA sequences [PDF]

, 1987
Tomato protoplasts have been transformed with plasmid DNA's, containing a chimeric kanamycin resistance gene and putative tomato origins of replication.
Zabel, Pim, Jongsma, M., Koornneef, Maarten, Koornneef, M., Hille, Jacques,, Hille, J., Jongsma, Maarten, Zabel, P., Jongsma, Maarten,, Koornneef, Maarten,, Zabel, Pim,, Hille, Jacques   +11 more
core   +2 more sources

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, 2018
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target.
Sairy Hernandez, Jing Qing, Rebecca Hong Thibodeau, Xiangnan Du, Summer Park, Hyang-Mi Lee, Min Xu, Soyoung Oh, Armando Navarro, Meron Roose-Girma, Robert J. Newman, Soren Warming, Michelle Nannini, Deepak Sampath, Jeong M. Kim, Jane L. Grogan, Ira Mellman   +16 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Scientific Reports, 2021
Regression models are often used to predict age of an individual based on methylation patterns. Artificial neural network (ANN) however was recently shown to be more accurate for age prediction.
Zhonghui Thong, Jolena Ying Ying Tan, Eileen Shuzhen Loo, Yu Wei Phua, Xavier Liang Shun Chan, Christopher Kiu-Choong Syn   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source