Results 41 to 50 of about 2,995,257 (170)

Identification of novel citramalate biosynthesis pathways in Aspergillus niger

Fungal Biology and Biotechnology, 2019
Background The filamentous fungus Aspergillus niger is frequently used for industrial production of fermentative products such as enzymes, proteins and biochemicals. Notable examples of industrially produced A.
Abeer H. Hossain, Aiko Hendrikx, Peter J. Punt   +2 more
doaj   +1 more source

Accurate genome-wide phasing from IBD data

BMC Bioinformatics, 2022
As genotype databases increase in size, so too do the number of detectable segments of identity by descent (IBD): segments of the genome where two individuals share an identical copy of one of their two parental haplotypes, due to shared ancestry.
Keith Noto, Luong Ruiz
doaj   +1 more source

Itaconic acid degradation in Aspergillus niger: the role of unexpected bioconversion pathways

Fungal Biology and Biotechnology, 2019
Background Itaconic acid (IA), a C5-dicarboxylic acid, has previously been identified as one of the top twelve biochemicals that can be produced by biotechnological means.
Abeer H. Hossain, Alexander Ter Beek, Peter J. Punt   +2 more
doaj   +1 more source

Finding Needle in the Haystack: “Kasur’s Bogeyman” Brought to Justice by Geographic Profiling and Mass DNA Screening

Brazilian Journal of Forensic Sciences, Medical Law and Bioethics, 2021
This article describes the application of the concept of geographic profiling in hunting a serial child rapist in Kasur, Pakistan. It also discusses, how DNA became the prime witness against the serial rapist in the court of law.
Muhammad Ahsan Butt, Talha Bin Rahat, Nasir Siddique, Madiha Shad, Sajjad Ahmad, Qazi Laeeque Ahmed, Muhammad Amjad, Mohammad Ashraf Tahir   +7 more
doaj   +1 more source

HPK1 citron homology domain regulates phosphorylation of SLP76 and modulates kinase domain interaction dynamics

Nature Communications
Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell receptor signaling and as such is an attractive target for cancer immunotherapy.
Avantika S. Chitre, Ping Wu, Benjamin T. Walters, Xiangdan Wang, Alexandre Bouyssou, Xiangnan Du, Isabelle Lehoux, Rina Fong, Alisa Arata, Joyce Chan, Die Wang, Yvonne Franke, Jane L. Grogan, Ira Mellman, Laetitia Comps-Agrar, Weiru Wang   +15 more
doaj   +1 more source

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, 2018
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target.
Sairy Hernandez, Jing Qing, Rebecca Hong Thibodeau, Xiangnan Du, Summer Park, Hyang-Mi Lee, Min Xu, Soyoung Oh, Armando Navarro, Meron Roose-Girma, Robert J. Newman, Soren Warming, Michelle Nannini, Deepak Sampath, Jeong M. Kim, Jane L. Grogan, Ira Mellman   +16 more
doaj   +1 more source

Artificial neural network, predictor variables and sensitivity threshold for DNA methylation-based age prediction using blood samples

Scientific Reports, 2021
Regression models are often used to predict age of an individual based on methylation patterns. Artificial neural network (ANN) however was recently shown to be more accurate for age prediction.
Zhonghui Thong, Jolena Ying Ying Tan, Eileen Shuzhen Loo, Yu Wei Phua, Xavier Liang Shun Chan, Christopher Kiu-Choong Syn   +5 more
doaj   +1 more source

Pengaruh Merokok terhadap Keefektivitasan Terapi Hipertensi pada Penderita Hipertensi Perokok Di Empat Puskesmas Tahun 2017

Journal of Tropical Pharmacy and Chemistry, 2017
Hypertension is a chronic condition of the mesh where blood pressure rises above normalized blood pressure. This study aims to measure the effect of smoking on the effectiveness of hypertension therapy in patients with hypertension of smokers at ...
Dna Raras Mardena, Anjar Mahardian Kusuma   +1 more
doaj   +1 more source

The DNA–DNA spacing in gemini surfactants–DOPE–DNA complexes

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
Gemini surfactants from the homologous series of alkane-α,ω-diyl-bis(dodecyldimethylammonium bromide) (CnCS12, number of spacer carbons n=2-12) and dioleoylphosphatidylethanolamine (DOPE) were used for cationic liposome (CL) preparation. CLs condense highly polymerized DNA creating complexes.
Pullmannova, P., Funari, S. S., Devinsky, F., Uhrikova, D.   +3 more
openaire   +3 more sources

Method for systematic targeted isolation of homologous cDNA fragments in a multiplex format

BioTechniques, 2004
In this study, a two-step method for systematic multiplex cloning of homologous cDNAs from related species was developed. The first step, called MUCH (multiplex cloning of homologous genes), is cloning of partial but authentic cDNA fragments of ...
Reiko Ohara, Hisashi Koga, Reiko Kikuno, Osamu Ohara   +3 more
doaj   +1 more source