Results 21 to 30 of about 4,554,738 (310)

Overall survival in patients with advanced non-small cell lung cancer with KRAS G12C mutation with or without STK11 and/or KEAP1 mutations in a real-world setting

BMC Cancer, 2023
Background KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC.
Cristina Julian, Navdeep Pal, Anda Gershon, Marie Evangelista, Hans Purkey, Peter Lambert, Zhen Shi, Qing Zhang   +7 more
doaj   +1 more source

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

Genome Medicine, 2023
Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities ...
Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua S. Kaminker, David H. Hackos, G. Scott Chandler, Mark I. McCarthy, Tushar Bhangale   +9 more
doaj   +1 more source

Publicidad y cultura. Las tecnologías de la información y de la comunicación como escenario de la persuasión.

Comunicação e Sociedade, 2012
El presente artículo se entiende dentro de una interesante iniciativa promovida por la Universidad do Minho que vio la luz por primera vez en octubre de 2004. El I Seminario Internacional de Comunicación Persuasiva planteó una cuestión más que relevante:
Dña. Charo Sádaba
doaj   +1 more source

Linear DNA amplicons as a novel cancer vaccine strategy

Journal of Experimental & Clinical Cancer Research, 2022
Background DNA-based vaccines represent a simple, safe and promising strategy for harnessing the immune system to fight infectious diseases as well as various forms of cancer and thus are considered an important tool in the cancer immunotherapy toolbox ...
Antonella Conforti, Erika Salvatori, Lucia Lione, Mirco Compagnone, Eleonora Pinto, Clay Shorrock, James A. Hayward, Yuhua Sun, Ben Minghwa Liang, Fabio Palombo, Brian Viscount, Luigi Aurisicchio   +11 more
doaj   +1 more source

DNA knots and DNA supercoiling [PDF]

Cell Cycle, 2011
Keywords: DNA topoisomerases; DNA topology; DNA structure Reference EPFL-ARTICLE-167094doi:10.4161/cc.10.9.15293View record in Web of Science Record created on 2011-06-24, modified on 2017-05 ...
Witz, Guillaume, Dietler, Giovanni, Stasiak, Andrzej   +2 more
openaire   +3 more sources

Identification of QTLs for root color and carotenoid contents in Japanese orange carrot F2 populations

Scientific Reports, 2022
Carrot is a major source of provitamin A in a human diet. Two of the most important traits for carrot breeding are carotenoid contents and root color.
Taeko Shibaya, Chika Kuroda, Hisano Tsuruoka, Chiharu Minami, Akiko Obara, Shinobu Nakayama, Yoshie Kishida, Takayoshi Fujii, Sachiko Isobe   +8 more
doaj   +1 more source

Transcriptome analysis of Clavibacter michiganensis subsp. michiganensis-infected tomatoes: a role of salicylic acid in the host response

BMC Plant Biology, 2021
Bacterial canker of tomato (Solanum lycopersicon) caused by the Gram-positive bacterium Clavibacter michiganensis subsp. michiganensis (Cmm) is an economically important disease.
Naoki Yokotani, Yoshinori Hasegawa, Masaru Sato, Hideki Hirakawa, Yusuke Kouzai, Yoko Nishizawa, Eiji Yamamoto, Yoshiki Naito, Sachiko Isobe   +8 more
doaj   +1 more source

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands

Nature Communications, 2020
The RNase activity of Inositol-Requiring Enzyme 1 (IRE1) can be allosterically regulated by ATP-competitive inhibitors of the IRE1 kinase domain. Here, the authors identify ATP-competitive IRE1 RNase activators with improved selectivity and cellular ...
Elena Ferri, Adrien Le Thomas, Heidi Ackerly Wallweber, Eric S. Day, Benjamin T. Walters, Susan E. Kaufman, Marie-Gabrielle Braun, Kevin R. Clark, Maureen H. Beresini, Kyle Mortara, Yung-Chia A. Chen, Breanna Canter, Wilson Phung, Peter S. Liu, Alfred Lammens, Avi Ashkenazi, Joachim Rudolph, Weiru Wang   +17 more
doaj   +1 more source

CRISPAltRations: A validated cloud-based approach for interrogation of double-strand break repair mediated by CRISPR genome editing

Molecular Therapy: Methods & Clinical Development, 2021
CRISPR systems enable targeted genome editing in a wide variety of organisms by introducing single- or double-strand DNA breaks, which are repaired using endogenous molecular pathways.
Gavin Kurgan, Rolf Turk, Heng Li, Nathan Roberts, Garrett R. Rettig, Ashley M. Jacobi, Lauren Tso, Morgan Sturgeon, Massimo Mertens, Roel Noten, Kurt Florus, Mark A. Behlke, Yu Wang, Matthew S. McNeill   +13 more
doaj   +1 more source

Genotoxikus hatásra bekövetkező funkcionális és strukturális DNS változások = Functional and structural changes in DNA upon genotoxic effects [PDF]

, 2008
Morfológiai és biokémiai vizsgálataink arra utalnak, hogy a a genotoxikus hatások kategorizálhatók az okozott kromatin változások alapján. A kemotoxikus változások potenciális diagnosztikus jelentősége miatt vizsgáltuk a nehézfémek (elsősosrban kadmium) (
Szepessy, Edit, Rőszer, Tamás, Bánfalvi, Gáspár, Jenei, Zsolt, Serfőző, Zoltán, Nagy, Gábor György, B. Kiss, Zsigmond   +6 more
core   +1 more source