Results 11 to 20 of about 2,995,257 (170)
Proceedings of the National Academy of Sciences, 1998 A DNA structure is described that can cleave single-stranded DNA oligonucleotides in the presence of ionic copper. This “deoxyribozyme” can self-cleave or can operate as a bimolecular complex that simultaneously makes use of duplex and triplex interactions to bind and cleave separate DNA substrates.
N, Carmi, S R, Balkhi, R R, Breaker
openaire +2 more sources
Microbiome, 2023 Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation and ...
Jordan S. Mar +11 more
doaj +1 more source
Phosphorylating DNA with DNA [PDF]
Proceedings of the National Academy of Sciences, 1999 Nearly 50 individual DNAs with polynucleotide kinase-like activity were isolated from a random-sequence pool by using in vitro selection. Each self-phosphorylating deoxyribozyme makes use of one or more of the eight standard NTPs or dNTPs as a source of activated phosphate.
Y, Li, R R, Breaker
openaire +2 more sources
mAbs, 2022 Rapid release of biopharmaceutical products enables a more efficient drug manufacturing process. Multi-attribute methods that target several product quality attributes (PQAs) at one time are an essential pillar of the rapid-release strategy.
Bingchuan Wei +25 more
doaj +1 more source
Optimized design parameters for CRISPR Cas9 and Cas12a homology-directed repair
Scientific Reports, 2021 CRISPR–Cas proteins are RNA-guided nucleases used to introduce double-stranded breaks (DSBs) at targeted genomic loci. DSBs are repaired by endogenous cellular pathways such as non-homologous end joining (NHEJ) and homology-directed repair (HDR ...
Mollie S. Schubert +7 more
doaj +1 more source
BMC Plant Biology, 2023 Background Plant genome information is fundamental to plant research and development. Along with the increase in the number of published plant genomes, there is a need for an efficient system to retrieve various kinds of genome-related information from ...
Hisako Ichihara +17 more
doaj +1 more source
BMC Cancer, 2023 Background KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC.
Cristina Julian +7 more
doaj +1 more source
DNA demethylation by DNA repair [PDF]
Trends in Genetics, 2009 Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process.
Gehring, Mary +2 more
openaire +3 more sources
Genome Medicine, 2023 Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities ...
Zia Khan +9 more
doaj +1 more source
DNA methylation and DNA methyltransferases [PDF]
Epigenetics & Chromatin, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding mammalian genes was believed to be at least five times greater than the actual number, and when it was ...
John R. Edwards +3 more
openaire +5 more sources