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Mutagenicity and Repair of Acrolein Adduct to Cytosine. [PDF]
Int J Mol SciDylewska M +3 more
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Identifying Novel DNA Adducts in Amphipods and Developing Sample Preparation for Adductomics Using Dispersive Solid-Phase Extraction. [PDF]
Environ Sci TechnolKhan Z +6 more
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Long-Patch Base Excision Repair of 5'-DNA-Peptide Cross-Links Derived from Abasic DNA Lesions. [PDF]
BiochemistryBryan C, Cepeda J, Wei X, Yang K.
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Medical Hypotheses, 2019
DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
B K, Puri, C, Ijeh, J A, Monro
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DNA adducts are associated with a number of diseases, including cancer. Based on a recent report by our group, the aim of this study was to test the hypothesis that DNA adducts can be removed by means of one or more of the following three intervention programmes: intermittent whole-body hyperthermia; detoxification; and cell repair.
B K, Puri, C, Ijeh, J A, Monro
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Toxicology, 1995
Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
K, Hemminki, H, Autrup, A, Haugen
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Application of methods for the measurement of DNA and protein adducts in environmental studies was surveyed. The methods included the 32P-postlabelling assay, immunoassay and synchronous fluorescence spectroscopy for DNA adducts. Additionally, methods for detecting excreted urinary RNA and DNA adducts were discussed.
K, Hemminki, H, Autrup, A, Haugen
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Toxicology Letters, 1995
The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
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The types of occupational groups studied by postlabelling include foundry, coke oven and aluminium workers, roofers, garage and terminal workers, car mechanics and chimney sweeps. There does not seem to be a direct relationship between the exposure and adduct levels.
openaire +3 more sources
DNA adducts of halogenated hydrocarbons
Journal of Cancer Research and Clinical Oncology, 1986Although formation of DNA adducts has been postulated for several halomethanes, no chemical identification of such adducts has been performed so far. There is, however, evidence that methyl chloride does not act biologically as a DNA methylating agent. 1,2-Dichloroethane and 1,2-dibromoethane are activated through conjugation with glutathione. There is
H M, Bolt +3 more
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DNA Adduct-Directed Synthetic Nucleosides
Accounts of Chemical Research, 2019Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O6-alkylguanine ( O6-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis.
Michael H. Räz +3 more
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DNA adducts in bronchial biopsies
International Journal of Cancer, 1991AbstractTo investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐surgical patients, endobronchial biopsies were obtained from 78 patients undergoing routine diagnostic bronchoscopy. Lung cancer was present in 37 (47%) of the patients.
B P, Dunn +6 more
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DNA adducts from chemotherapeutic agents
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1996The guiding principle of early work was the hypothesis that the anti-cancer alkylating drugs acted through their ability to cross-link macromolecules essential for cell division. Not long afterwards, DNA was specified as the essential target, and support for the hypothesis came from evidence that the archetypal agent, mustard gas, could link guanine ...
P D, Lawley, D H, Phillips
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