Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling [PDF]
, 1997 Jamal M. Arif
openalex +1 more source
ChemistryOpen, EarlyView.This study evaluates the nephroprotective potential of Fraxinus hookeri Wenz. (F. hookeri), a medicinal plant of the Oleaceae family, against CCl4‐induced oxidative stress. The findings demonstrate its ability to restore antioxidant defenses, renal function markers, and DNA integrity while reducing lipid peroxidation and histopathological damage.
Raheela Sarwar +9 more
wiley +1 more source
Prevention of Lipid Peroxidation-derived Cyclic DNA Adduct and Mutation in High-Fat Diet-induced Hepatocarcinogenesis by Theaphenon E. [PDF]
Cancer Prev Res (Phila), 2018 Coia H +16 more
europepmc +1 more source
The Impact of Conjugation Mode and Site on Tubulysin Antibody‐Drug‐Conjugate Efficacy and Stability
ChemistryOpen, EarlyView.Two biotransformation events, payload metabolism and deconjugation, are profiled using immuno‐capture ligand‐binding assays and mass spectrometry. The site‐specific antibody‐drug conjugate (ADC) demonstrates superior in vivo efficacy and favorable pharmacokinetics compared to site‐directed or random ADCs.
Sayumi Yamazoe +13 more
wiley +1 more source
Microfluidic array for simultaneous detection of DNA oxidation and DNA-adduct damage. [PDF]
Analyst, 2016 Song B +6 more
europepmc +1 more source
DNA adducts in environmental, occupational and life-style studies in human biomonitoring.
, 1996 K. Hemminki +3 more
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DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue TMmice does not correlate with mutagenicity [PDF]
, 1998 Masako Ochiai +6 more
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Anti‐Inflammatory Saponins From an Edible Aquatic Plant Nymphoides hydrophylla
Phytochemical Analysis, EarlyView.ABSTRACT Introduction The present investigation of Nymphoides hydrophylla is a Taiwan indigenous edible aquatic plant, belongs to the Menyanthaceae family, and has been used as a traditional food with potential medicinal values against fever, insect bites, ulcer, and skin diseases.
Ching‐Yeu Chen +6 more
wiley +1 more source
Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. [PDF]
Proc Natl Acad Sci U S A, 2018 Yang Y +8 more
europepmc +1 more source
Genetic Diagnosis and Clinical Features of Fetuses With Congenital Diaphragmatic Hernia
Prenatal Diagnosis, EarlyView.ABSTRACT Objective Congenital diaphragmatic hernia (CDH) is a rare abnormality with highly heterogeneous genetic causes. This study investigated chromosomal and monogenic abnormalities in fetal CDH patients and evaluated the efficacy of chromosomal microarray analysis (CMA) and whole‐exome sequencing (WES) for genetic diagnosis.
Yan Lü +18 more
wiley +1 more source