Results 171 to 180 of about 108,337 (292)

Direct Selection of Functional De Novo Macrocycles for Activation of On‐Cellulo Insulin Receptor

open access: yesAngewandte Chemie, EarlyView.
A live‐cell screening platform, RaPID‐ExCells, integrates mRNA display‐derived macrocyclic peptide libraries with functional selection against native cell‐surface receptors. Application to the insulin receptor enabled de novo discovery of a macrocyclic agonist that activates endogenous signaling despite weak in vitro binding, highlighting the power of ...
Yun‐Hsuan Kuo   +3 more
wiley   +2 more sources

A taxonomically reliable DNA barcode reference library for North Sea macrobenthos. [PDF]

open access: yesSci Data
Christodoulou M   +14 more
europepmc   +1 more source

Assessing sequence heterogeneity in Chlorellaceae DNA barcode markers for phylogenetic inference. [PDF]

open access: yesJ Genet Eng Biotechnol, 2023
Wong EB   +4 more
europepmc   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov   +14 more
wiley   +1 more source

A Reference DNA Barcode Library for UK Fungi associated with Bark and Ambrosia Beetles. [PDF]

open access: yesSci Data
Ceballos-Escalera A   +4 more
europepmc   +1 more source

Combined Long‐Read Genome and Transcriptome Sequencing Establishes Novel Variants in MEGF8 as the Cause for Carpenter Syndrome Type 2

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carpenter syndrome type 2 (CRPT2) is a rare autosomal recessive disease mainly characterized by craniosynostosis and polysyndactyly. CRPT2 is the rarer subtype of Carpenter syndrome (CRPTS) and is caused by biallelic variants in the multiple epidermal growth factor‐like domains 8 gene (MEGF8).
Kiana Rashidi   +11 more
wiley   +1 more source

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