Results 171 to 180 of about 107,065 (275)

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

A Comprehensive DNA Barcode Reference Library for the Macroinvertebrates of Scottish Seagrass Beds Using Oxford Nanopore Flongle Flowcells. [PDF]

Ecol Evol
Ross EG, Piertney SB, Sigwart JD, Crook NF, Moreau A, Layton KKS.   +5 more
europepmc   +1 more source

The DNA barcode identification of Dalbergia odorifera T. Chen and Dalbergia tonkinensis Prain. [PDF]

BMC Plant Biol, 2023
Wang W, Chen B, Ma R, Qiao M, Fu Y.
europepmc   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

A new species and record of <i>Xestochironomus</i> Sublette & Wirth, 1972 (Diptera, Chironomidae) from the Dominican Republic, with males and females associated by DNA barcode. [PDF]

Zookeys
Fusari LM, Höcherl A, Chimeno C, Baranov V.   +3 more
europepmc   +1 more source

DNA Barcodes [PDF]

, 2012
openaire   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Building a DNA barcode library of commercially exploited fish genetic resources (FGR) of the Gomti River, Ganga basin, implications for conservation and management. [PDF]

Sci Rep
Sahu A, Singh M, Sarkar UK.
europepmc   +1 more source

DNA Barcode library of the endemic-rich avifauna of the oceanic islands of the Gulf of Guinea. [PDF]

Biodivers Data J, 2023
Melo M, Covas R, de Lima RF, Veiga da Horta O, do Bom Jesus C, Barros da Veiga M, Samba S, Fonseca R, Cabinda G, Viegas L, Silva TL, Mata VA, Beja P, Ferreira S.   +13 more
europepmc   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source