Results 51 to 60 of about 53,036 (303)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Optimization of Natural Deep Eutectic Solvent-Assisted Extraction of Rosmarinic Acid from Thunbergia laurifolia Lindl. and Evaluation of Antioxidant Activity

Molecules
Thunbergia laurifolia Lindl. is a plant known for its promising biological activity, including antioxidant and anti-inflammatory activities, and a rich source of rosmarinic acid (RA). The extraction of T.
Krittima Kriengsaksri, Wisuwat Thongphichai, Tamonwan Uttarawichien, Jasadakorn Khoochonthara, Pasarapa Towiwat, Suchada Sukrong   +5 more
doaj   +1 more source

Reliable DNA barcoding performance proved for species and island populations of comoran squamate reptiles. [PDF]

PLoS ONE, 2013
In the past decade, DNA barcoding became increasingly common as a method for species identification in biodiversity inventories and related studies.
Oliver Hawlitschek, Zoltán T Nagy, Johannes Berger, Frank Glaw   +3 more
doaj   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

DNA barcoding for identification of Erebia euryale butterflies in the Belluno prealps

, 2023
openMolto spesso non è semplice identificare le specie quando queste sono morfologicamente molto simili e vivono in simpatria. Tra i lepidotteri, il genere Erebia mostra delle specie morfologicamente simili che si sovrappongono nella loro distribuzione ...
ANGIARI, VALENTINA
core  

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

DNA barcoding, forensics, and application of DNA chip technology

, 2010
Among the 1,121 recognized fish species in Korean waters, approximately 9% (12 Elasmobranchii and 88 Actinopterygii species) have been barcoded with regards to the COI sequences. The DNA barcodes have been used for investigation of correctness in species
이유철, 이강현, 김고은, 김성, 강미혜, Habib, 배세진, Seung Yong Hwang, 정다금, 오지나, 이윤호   +10 more
core   +1 more source

Unveiling South African insect diversity: DNA barcoding’s contribution to biodiversity data

South African Journal of Science
Insects are one of the most species-rich groups on Earth. They comprise much of animal diversity and play vital roles in ecosystems, including pollination, pest control, and decomposition.
Ross D. Stewart, Michelle van der Bank, T. Jonathan Davies   +2 more
doaj   +1 more source

Classification of sharks in the Egyptian Mediterranean waters using morphological and DNA barcoding approaches. [PDF]

PLoS ONE, 2011
The identification of species constitutes the first basic step in phylogenetic studies, biodiversity monitoring and conservation. DNA barcoding, i.e. the sequencing of a short standardized region of DNA, has been proposed as a new tool for animal species
Marie Moftah, Sayeda H Abdel Aziz, Sara Elramah, Alexandre Favereaux   +3 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source