Results 61 to 70 of about 40,802 (260)

Milk sphingolipids as functional components

Academia Nutrition and Dietetics
Milk sphingomyelin (SM) and gangliosides represent key bioactive sphingolipids in dairy products increasingly recognized for their multifaceted health benefits.
Bhavbhuti M. Mehta, Shankar N. Mutkule, Essam Hebishy, Nivedita Datta   +3 more
doaj   +1 more source

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Anti-inflammatory activity of Curcuma wanenlueanga Saensouk, Thomudtha & Boonma rhizomes and the search for its bioactive markers by harmonizing bioassay-guided isolation and network pharmacology

BMC Complementary Medicine and Therapies
Background Rhizomes of Curcuma wanenlueanga Saensouk, Thomudtha & Boonma have been used in Thai traditional medicine and are included as an ingredient in a Thai traditional liniment formula listed by the Ministry of Public Health of Thailand for treating
Wisuwat Thongphichai, Hasriadi Hasriadi, Peththa Wadu Dasuni Wasana, Sanith Sri Jayashan, Boonchoo Sritularak, Pasarapa Towiwat, Suchada Sukrong   +6 more
doaj   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Anthropogenic Pressures, Rather Than Plant Vigour, Promote Insect Herbivory Rates on Securidaca longepedunculata Along Elevation in a South African Woodland

Ecology and Evolution
Understanding why some plants experience greater herbivory than others is central to predicting population dynamics and ecosystem resilience. We tested the plant vigour hypothesis, the resource concentration hypothesis and the role of anthropogenic ...
Mashudu Patience Mamathaba, Bopaki Phogole, Orou G. Gaoue, Kowiyou Yessoufou   +3 more
doaj   +1 more source

A Taxonomic Review of South African Indigenous Meliaceae Using Molecular Systematics and Anatomical Data

Diversity
The Meliaceae are broadly distributed worldwide, with about 50 genera and over 1400 species. There are 11 genera in South Africa, with 13 indigenous and three naturalized species.
Mariam Oyefunke Oyedeji Amusa, Ross Dylan Stewart, Michelle van der Bank, Ben-Erik van Wyk   +3 more
doaj   +1 more source

DNA barcoding Brooklyn (New York): A first assessment of biodiversity in Marine Park by citizen scientists.

PLoS ONE, 2018
DNA barcoding is both an important research and science education tool. The technique allows for quick and accurate species identification using only minimal amounts of tissue samples taken from any organism at any developmental phase.
Christine Marizzi, Antonia Florio, Melissa Lee, Mohammed Khalfan, Cornel Ghiban, Bruce Nash, Jenna Dorey, Sean McKenzie, Christine Mazza, Fabiana Cellini, Carlo Baria, Ron Bepat, Lena Cosentino, Alexander Dvorak, Amina Gacevic, Cristina Guzman-Moumtzis, Francesca Heller, Nicholas Alexander Holt, Jeffrey Horenstein, Vincent Joralemon, Manveer Kaur, Tanveer Kaur, Armani Khan, Jessica Kuppan, Scott Laverty, Camila Lock, Marianne Pena, Ilona Petrychyn, Indu Puthenkalam, Daval Ram, Arlene Ramos, Noelle Scoca, Rachel Sin, Izabel Gonzalez, Akansha Thakur, Husan Usmanov, Karen Han, Andy Wu, Tiger Zhu, David Andrew Micklos   +39 more
doaj   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source