Results 181 to 190 of about 54,243 (194)

Leadership and Sustainability in a Globalized World: Emerging Trends, Global Contexts, Key Challenges, and Effective Strategies

Business Strategy and the Environment, EarlyView.
ABSTRACT This systematic review analyzes 109 studies from top business journals, exploring the connection between leadership and sustainability, including key leadership styles, emerging trends, and challenges in integrating sustainability into organizational strategies and operations.
Muzhar Javed, Bilal. Bilal, Nacef Mouri, Muhammad Faisal   +3 more
wiley   +1 more source

Single-cell heterogeneity underpins antagonistic antibiotic interactions. [PDF]

Mol Syst Biol
Teuber Carvalho JP, Schultz D.
europepmc   +1 more source

Evaluation of gene editing in CHO cells using the Cas‐CLOVER system

Biotechnology Progress, EarlyView.
Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah, Efecan Aral, Michael Hoffman, Jennifer Tedstone, Thomas King, Jason Vitko, Maria João Sebastião, Jose M. Escandell, Mafalda M. Dias, Iona McCall, Daniel Machado, Victor Cairns, Christine DeMaria, John J. Scarcelli   +13 more
wiley   +1 more source

Chromosomal Instability and Telomere Attrition in Systemic Sclerosis: A Historical Perspective. [PDF]

Genes (Basel)
Artlett CM.
europepmc   +1 more source

Sequential, chromosome‐specific glutamine synthetase double knockout with Cas‐CLOVER establishes enhanced CHO platforms for cell line development

Biotechnology Progress, EarlyView.
This study established the first creation of a commercially available double GS knockout (DKO) from a single KO in CHO‐K1 cells, called CleanCut GS CHO using Cas‐CLOVER. When combined with the Harbor‐IN transposase system, CleanCut GS CHO cells demonstrated a highly antibody productivity.
Cintia Gomez Limia, Valeriya Steffey, Hsueh Che Cheng, Daniel Machado, Thomas Hart, Mark Cameron McHargue, Corey Brizzee, Jack Crawford   +7 more
wiley   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double-Strand Breaks. [PDF]

Bioessays
Gasser SM.
europepmc   +1 more source

PKA prevents the resection of DNA double-strand breaks and favours nonhomologous end-joining. [PDF]

Sci Rep
Khater-Sellou H, Dardillac E, Rabut E, Magdalou I, Ogryzko V, Guirouilh-Barbat J, Lopez BS.   +6 more
europepmc   +1 more source

Mitochondrial DNA Instability and Neuroinflammation: Connecting the Dots Between Base Excision Repair and Neurodegenerative Disease. [PDF]

Genes (Basel)
Pittman MN, Nelsen MB, Thompson MK, Prakash A.   +3 more
europepmc   +1 more source

The multiple layers of RNA response in double-strand break repair. [PDF]

Exp Mol Med
Lu Y, Storici F, Jeon Y.
europepmc   +1 more source