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Hepatitis B viral DNA integration occurs within three days of infection and is enhanced by ATR inhibition. [PDF]
Tumour Virus ResLi D +10 more
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DNA Double-Strand Break Repair Assay
Cold Spring Harbor Protocols, 2017DNA double-strand breaks (DSBs), arising during normal DNA metabolism or following exposure to mutagenic agents such as ionizing radiation can lead to chromosomal rearrangements and genome instability, and are potentially lethal if unrepaired. Therefore, understanding the mechanisms of DSB repair and misrepair, and identifying the factors involved in ...
Chen-Chun, Pai +2 more
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Transcription-coupled DNA double-strand break repair
DNA Repair, 2022The genomic DNA is constantly under attack by cellular and/or environmental factors. Fortunately, the cell is armed to safeguard its genome by various mechanisms such as nucleotide excision, base excision, mismatch and DNA double-strand break repairs.
Shalini, Guha, Sukesh R, Bhaumik
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DNA double‐strand breaks in mutagenesis
Environmental and Molecular Mutagenesis, 1993The DNA-double-strand break (dsb) appears to be the major lesion involved in chromosomal aberration formation. It is also very likely that the DNA dsb is the dominant lesion involved in radiation-induced mutagenesis. The dsb has been implicated as the primary lesion responsible for the induction of large deletions and, to a lesser extent, large ...
J W, Phillips, W F, Morgan
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Ubiquitylation in DNA double-strand break repair
DNA Repair, 2021Genome integrity is constantly challenged by various DNA lesions with DNA double-strand breaks (DSBs) as the most cytotoxic lesions. In order to faithfully repair DSBs, DNA damage response (DDR) signaling networks have evolved, which organize many multi-protein complexes to deal with the encountered DNA damage.
Mengfan, Tang, Siting, Li, Junjie, Chen
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DNA Double Strand Breaks and Chromosomal Aberrations
Cytogenetic and Genome Research, 2010DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal aberrations (CAs). The formation of CAs is dependent on many factors; some of these are discussed in this review. FISH methodologies have uncovered CA types which cannot be seen with the classical staining methods, and thereby widened our understanding of the origin ...
G. Obe, DURANTE, MARCO
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Coping with DNA double strand breaks
DNA Repair, 2010The repair of DNA double strand breaks (dsb) is important for maintaining the physical and genetic integrity of the genome. Moreover, in humans it is associated with the prevention of diseases such as immune deficiencies and cancer. This review briefly explores the fundamental strategies for repairing dsb, examines how cells maximize the fidelity of ...
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