Results 41 to 50 of about 167,723 (264)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Quaternary Code Correcting a Burst of at Most Two Deletion or Insertion Errors in DNA Storage
Entropy, 2021 Due to the properties of DNA data storage, the errors that occur in DNA strands make error correction an important and challenging task. In this paper, a new code design of quaternary code suitable for DNA storage is proposed to correct at most two ...
Thi-Huong Khuat, Sunghwan Kim
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Properties and Constructions of Constrained Codes for DNA-Based Data Storage
IEEE Access, 2020 We describe properties and constructions of constraint-based codes for DNA-based data storage which account for the maximum repetition length and AT/GC balance.
Kees A. Schouhamer Immink, Kui Cai
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
MethodsX, 2022 G-quadruplexes (G4s) are non-canonical DNA and RNA secondary structures that control gene regulation. A single nucleotide polymorphism (SNP) is a small genetic variation occurring within a DNA sequence and accounting for the variabilities between ...
Mona SAAD +3 more
doaj +1 more source
Malaya Journal of Matematik, 2023 In this paper, by using three different methods, the DNA codes are obtained from some codes over a family of the rings $D_{i}=D_{1}\left[ w_{2},...,w_{i}\right]/\left\langle w_{i}^{2}-w_{i},w_{i}w_{j}-w_{j}w_{i}\right\rangle $, where $% i=2,...,r,j=1,2,...r$ and $D_{1}=F_{2}+uF_{2}+w_{1}(F_{2}+uF_{2}),u^{2}=0,w_{1}^{2}=w_{1},uw_{1}=w_{1}u, F_{2}=\{0,1\}
null Abdullah DERTLI +1 more
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Rapid and robust assembly and decoding of molecular tags with DNA-based nanopore signatures
Nature Communications, 2020 Molecular tagging using DNA is an attractive option in cases that are not suitable for RFID tags or QR codes. Here, the authors present Porcupine, DNA tags directly classifiable from raw nanopore signals.
Kathryn Doroschak +6 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source