Results 61 to 70 of about 370,591 (311)
MethodsX, 2022 G-quadruplexes (G4s) are non-canonical DNA and RNA secondary structures that control gene regulation. A single nucleotide polymorphism (SNP) is a small genetic variation occurring within a DNA sequence and accounting for the variabilities between ...
Mona SAAD +3 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Rapid and robust assembly and decoding of molecular tags with DNA-based nanopore signatures
Nature Communications, 2020 Molecular tagging using DNA is an attractive option in cases that are not suitable for RFID tags or QR codes. Here, the authors present Porcupine, DNA tags directly classifiable from raw nanopore signals.
Kathryn Doroschak +6 more
doaj +1 more source
Uses Of Transgenic Animals Containing A Type X Collagen Mutant [PDF]
, 2001 This Invention Provides An Isolated Dna Comprising The Sequence Which Codes For A Mutated Collagen X Or A Portion Thereof Wherein The Expression Of Said Dna Regulates Bone Growth.
core
On Optimal Family of Codes for Archival DNA Storage
, 2016 DNA based storage systems received attention by many researchers. This includes archival and re-writable random access DNA based storage systems. In this work, we have developed an efficient technique to encode the data into DNA sequence by using non ...
Dhameliya, Vijay +3 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Is a genome a codeword of an error-correcting code? [PDF]
PLoS ONE, 2012 Since a genome is a discrete sequence, the elements of which belong to a set of four letters, the question as to whether or not there is an error-correcting code underlying DNA sequences is unavoidable. The most common approach to answering this question
Luzinete C B Faria +7 more
doaj +1 more source
Evolutionary approach to construct robust codes for DNA-based data storage
Frontiers in Genetics, 2023 DNA is a practical storage medium with high density, durability, and capacity to accommodate exponentially growing data volumes. A DNA sequence structure is a biocomputing problem that requires satisfying bioconstraints to design robust sequences ...
Abdur Rasool +6 more
doaj +1 more source
Rates of DNA Sequence Profiles for Practical Values of Read Lengths
, 2016 A recent study by one of the authors has demonstrated the importance of profile vectors in DNA-based data storage. We provide exact values and lower bounds on the number of profile vectors for finite values of alphabet size $q$, read length $\ell$, and ...
Chang, Zuling +3 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source