Results 201 to 210 of about 736,909 (260)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

iFLinkC-EZ: A scalable and automatable method for the assembly of complex fusion proteins and multi-gene expression constructs based on the iFLinkC framework. [PDF]

Synth Syst Biotechnol
Kemp P, Blat Belmonte M, Schmidt M, Eisenhauer K, Gebhardt C, Kabuth K, Koeppl H, Stein V.   +7 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Defense-associated reverse transcriptases define an emerging class of noncanonical DNA-writing systems. [PDF]

Synth Syst Biotechnol
Tong Y.
europepmc   +1 more source

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis. [PDF]

Front Immunol
Chen H, Wu Y, Zhang K, Chen Z, Xu H, Xie C, Lin C, Pan X.   +7 more
europepmc   +1 more source

Quantitative Multiplex Digital PCR with Fluorescence-Encoded Nanoreactor Beads. [PDF]

Anal Chem
Hubold S, Kanitz L, Lemuth O, Engelmann I, Toepfer S, Brandes S, Liebe T, Fritsch F, Braun S, Reinicke M, Ehricht R, Ermantraut E.   +11 more
europepmc   +1 more source

Complete Mitochondrial Genome of <i>Haemulon plumierii</i> (Lacepède, 1801) Supports Its Use as a Sentinel Reef Fish. [PDF]

Genes (Basel)
Cañizares-Martínez MA, Zamora-Briseño JA, Rivera-Bustamante RF, Rodríguez-Canul R.   +3 more
europepmc   +1 more source

LRP1 in atherosclerosis: a hierarchical view of regulatory mechanisms and epigenetic knowledge gaps. [PDF]

Front Cell Dev Biol
Casale R, Chiabrando GA, Ceschin DG.
europepmc   +1 more source