Results 141 to 150 of about 127,811 (292)
A DNA computing methodology [PDF]
, 2004 A computação com DNA é um campo da Bioinformática que, através da manipulação de seqüências de DNA, busca a solução de problemas. Em 1994, o matemático Leonard Adleman, utilizando operações biológicas e manipulação de seqüências de DNA, solucionou uma ...
Isaia Filho, Eduardo +1 more
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 1997 DNA computing holds out the promise of important and signi cant connections between computers and living systems, as well as promising massively parallel computations. Before these promises are ful lled, however, importantchallenges related to errors and
Max Garzon +4 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular associative memory: An associative memory framework with exponential storage capacity for DNA computing [PDF]
Associative memory problem: Find the closest stored vector (in Hamming distance) to a given query vector. There are different ways to implement an associative memory, including the neural networks and DNA strands.
Salavati, Amir Hesam +2 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Minimum Finding with DNA Computing [PDF]
, 2003 Recently, DNA computing is one of powerful tools that can be designed for solving NP-complete problems. The powers of DNA computing are that it has great ability of massive data storage and it can process those data in parallel.
Hsu, Chie-Yao
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source