Results 161 to 170 of about 122,806 (254)

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics.

Chem Soc Rev
Takiguchi S, Takeuchi N, Shenshin V, Gines G, Genot AJ, Nivala J, Rondelez Y, Kawano R.   +7 more
europepmc   +1 more source

Gungnir codec enabling high error-tolerance and low-redundancy DNA storage through substantial computing power. [PDF]

Nat Commun
Zhang J, Chen L, Sun J, Li S, Zhou Y, Wu Z, Li C, Zheng Z, Luo R.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Detecting unannotated splicing events in short-read RNA-seq with SAMI, a UMI-aware Nextflow pipeline. [PDF]

Bioinformatics
Mareschal S, Wucher V, Huet S, Léonce C, Chabane K, Hayette S, Bringuier PP, Pinson S, Barritault M, Bardel C.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing. [PDF]

Sci Eng Ethics
Sirbu RA, Floridi L.
europepmc   +1 more source

DNA Computing. 5. A Survey of DNA Nanotechnology Based on DNA Computation.

The Journal of The Institute of Electrical Engineers of Japan, 2002
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

NEFFy: a versatile tool for computing the number of effective sequences. [PDF]

Bioinformatics
Haghani M, Bhattacharya D, Murali TM.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source