Results 181 to 190 of about 333,155 (283)

Deep convolutional and fully-connected DNA neural networks. [PDF]

Nat Commun
Liu X, Zheng Z, Liu P, Yang Z, Hu H, Wu M, Lou X, Xia F, Tao K, Li L, Dai J, Xiao X.   +11 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Harnessing DNA computing and nanopore decoding for practical applications: from informatics to microRNA-targeting diagnostics.

Chem Soc Rev
Takiguchi S, Takeuchi N, Shenshin V, Gines G, Genot AJ, Nivala J, Rondelez Y, Kawano R.   +7 more
europepmc   +1 more source

Efficient sampling of large-scale transition pathways and intermediate conformations in sub-mesoscopic protein complexes. [PDF]

Nat Commun
Scaramozzino D, Lee BH, Orellana L.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Omega Nucleic Acids (ΩNA), Ultimate Nucleic Acids for Future Technology. [PDF]

Molecules
Hamada S, Murayama K, Takezawa Y, Toyoda R, Kuzuya A.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Quantum biology: From mechanisms to medicine. [PDF]

Clin Transl Med
Sung JY, Cheong JH.
europepmc   +1 more source

Parallel computing with DNA: towards the anti-universal machine

, 1996
Conrad, M., Zauner, K.-P.
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