Results 201 to 210 of about 122,806 (254)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

DNA-Lipid Nanodiscs with a Polyethylene Glycol Interface. [PDF]

J Am Chem Soc
Chandrasekhar S, Maffeo C, Karanth S, Bricker R, Kabuga J, Nunes Gonçalves DP, Aksimentiev A, Schmidt TL.   +7 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A review of multi-omics integration techniques across five machine learning method families. [PDF]

Bioinform Adv
Olowolayemo A, Souag A, Sirlantzis K, Turner S, Wilson C.   +4 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Genome sequences of five <i>Streptomyces</i> type strains (<i>Streptomyces argenteolus</i>, <i>Streptomyces pratensis</i>, <i>Streptomyces puniceus</i>, <i>Streptomyces spiroverticillatus</i>, and <i>Streptomyces sundarbansensis</i>). [PDF]

Microbiol Resour Announc
Biessy A, Jayathissa A, Jordan W, Bennett M, Calo M, Filion M.   +5 more
europepmc   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications. [PDF]

Chem Sci
Hu Y, Zhang J, Shen K, Shen W, Lee HK, Tang S.   +5 more
europepmc   +1 more source

Identifying membrane-bound transcriptional regulatory proteins from rare but evolutionarily conserved domain combinations. [PDF]

Nucleic Acids Res
Lee M, Jang Y, Guo Q, Punyamurtula U, Choi J, Kim J, Marcotte EM.   +6 more
europepmc   +1 more source

BioPipelines: Accessible Computational Protein and Ligand Design for Chemical Biologists. [PDF]

Comput Struct Biotechnol J
Quargnali G, Rivera-Fuentes P.
europepmc   +1 more source