Results 101 to 110 of about 8,402,765 (253)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Cellular DNA content and clinicopathologic correlations in chondroid tumors

Acta Orthopaedica et Traumatologica Turcica, 2021
The process of differentiating between cartilage tumors is complex. Flow cytometric DNA analysis was performed on 23 chondroid tumors out of which 5 were enchondroma, 5 were Grade I, 4 were Grade II, 5 were Grade III and 4 were mesenchymal chandrosarcoma.
Sergülen Dervişoğlu, Aslı Kasabaligil, Altan Yalciner, Buge Oz, Suha Goksel, Murat Hiz, Ajlan Kasabaligil, Gunay Girisken   +7 more
doaj  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Repair of oxidatively-induced clustered DNA lesions, after exposure of human cancer cells to ionizing radiation

, 2017
In the present thesis, the induction and repair of complex DNA lesions, double strand breaks (DSBs) of high complexity accompanied by oxidatively-induced base lesions in their close vicinity were studied after exposure to ionizing radiation (IR) of ...
Νικητάκη, Ζαχαρένια, Νικητάκη, Ζαχαρένια, Nikitaki, Zacharenia   +2 more
core   +1 more source

The role of genome size and heterochromatin on maize flowering time

Crop Breeding and Applied Biotechnology
Maize exhibits extensive variability in vegetative cycle length (VCL), a trait essential for environmental adaptation. This study investigates relationships among genome size, knob heterochromatin content, and VCL in three inbred lines with contrasting ...
Graciela Esther González, Alexandra Marina Gottlieb, Lidia Poggio   +2 more
doaj  

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

PLOJDY ANALYSIS AND DNA CONTENT OF MUTANT BANANA

Biotropia: The Southeast Asian Journal of Tropical Biology, 2002
Mutagens cause random changes in the nuclear DNA or cytoplasmic organelles, resulting in gene, chromosomal or genomic mutations and hence, create variability.
MAK CHAI, ABDELGADIR RAYIS SHADIA, ROFINA YASMIN OTHMAN   +2 more
doaj  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source