Results 171 to 180 of about 8,402,765 (253)

Peripheral blood leukocyte mitochondrial DNA content and risk of lung cancer. [PDF]

Transl Lung Cancer Res, 2022
Kennedy GT, Mitra N, Penning TM, Whitehead AS, Vachani A.   +4 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cells. [PDF]

PLoS Pathog
Moore M, Kong J, Akmel A, Thomas MA.
europepmc   +1 more source

Estimation of Nuclear DNA Content in Some Aegilops Species: Best Analyzed Using Flow Cytometry. [PDF]

Genes (Basel), 2022
Najafi S, Ulker M, Oral E, Tuncturk R, Tuncturk M, Sayyed RZ, Perveen K, Poczai P, Cseh A.   +8 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Mitochondrial DNA content and methylation in sperm of patients with asthenozoospermia. [PDF]

J Assist Reprod Genet
Geng Q, Gao R, Sun Y, Chen S, Sun L, Li W, Li Z, Zhao Y, Zhao F, Zhang Y, Li A, Liu H.   +11 more
europepmc   +1 more source

Three recent sex chromosome-to-autosome fusions in a Drosophila virilis strain with high satellite DNA content. [PDF]

Genetics, 2023
Flynn JM, Hu KB, Clark AG.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Determination of DNA content as quality control in decellularized tissues: challenges and pitfalls. [PDF]

Regen Biomater
Philips C, Terrie L, Muylle E, Thorrez L.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source