Results 131 to 140 of about 106,656 (293)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Genetic and neuro-epigenetic effects of divergent artificial selection for feather pecking behaviour in chickens

BMC Genomics
Feather pecking (FP) is a repetitive behaviour in chickens, influenced by genetic, epigenetic, and environmental factors, similar to behaviours seen in human developmental disorders (e.g., hyperactivity, autism).
Elske N. de Haas, Fábio Pértille, Joergen B. Kjaer, Per Jensen, Carlos Guerrero-Bosagna   +4 more
doaj   +1 more source

Copy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysis [PDF]

, 2018
Ling Ren, Jingwei Liu, Kaihua Gou, Chengzhong Xing   +3 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Analysis of mitochondrial DNA sequence and copy number variation across five high-altitude species and their low-altitude relatives [PDF]

, 2018
Rui Liu, Long Jin, Keren Long, Qianzi Tang, Jideng Ma, Xun Wang, Li Zhu, Anan Jiang, Guoqing Tang, Yanzhi Jiang, Xuewei Li, Mingzhou Li   +11 more
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Identification of genes with correlated patterns of variations in DNA copy number and gene expression level in gastric cancer

, 2007
Sanghwa Yang, Hei‐Cheul Jeung, Ha Jin Jeong, Yeon Ho Choi, Ji Eun Kim, Jae-Joon Jung, Sun Young Rha, Woo Ick Yang, Hyun Cheol Chung   +8 more
openalex   +1 more source

Complex DNA structures trigger copy number variation across thePlasmodium falciparumgenome [PDF]

, 2018
Adam C. Huckaby, Claire S Granum, Maureen A. Carey, Karol Szlachta, Basel M. Al‐Barghouthi, Yuh‐Hwa Wang, Jennifer L. Güler   +6 more
openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress

, 2008
Catherine Aiken, Tereza Cindrová‐Davies, Martin H. Johnson   +2 more
openalex   +1 more source