Results 1 to 10 of about 5,360,816 (265)

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Signal Transduction and Targeted Therapy, 2021
Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is typically based on this property of cancers.
Ruixue Huang, P. Zhou
semanticscholar   +1 more source

HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells

Cell Death and Disease, 2022
The Hsp70-binding protein 1 (HspBP1) belongs to a family of co-chaperones that regulate Hsp70 activity and whose biological significance is not well understood.
Cha Kyung Youn, Jung-Hee Lee, Gurusamy Hariharasudhan, Hong Beum Kim, Jeeho Kim, Sumi Lee, Sung-Chul Lim, Sang-Pil Yoon, Sang-Gon Park, In-Youb Chang, Ho Jin You   +10 more
doaj   +1 more source

DNA Damage Atlas: an atlas of DNA damage and repair

Nucleic Acids Research, 2023
DNA damage and its improper repair are the major source of genomic alterations responsible for many human diseases, particularly cancer. To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide ...
Yu Liang, Qingqing Yuan, Qijie Zheng, Zilv Mei, Yawei Song, Huan Yan, Jiajie Yang, Shuheng Wu, Jiao Yuan, Wei Wu   +9 more
semanticscholar   +1 more source

Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

Scientific Reports, 2021
In response to UV irradiation, translesion DNA synthesis (TLS) utilizes specialized DNA polymerases to bypass replication-blocking lesions. In a well-established polymerase switch model, Polη is thought to be a preferred TLS polymerase to insert correct ...
Tonghui Bi, Xiaohong Niu, Chunping Qin, Wei Xiao   +3 more
doaj   +1 more source

Lysine Crotonylation: An Emerging Player in DNA Damage Response

Biomolecules, 2022
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated ...
Yuqin Zhao, Shuailin Hao, Wenchi Wu, Youhang Li, Kaiping Hou, Yu Liu, Wei Cui, Xingzhi Xu, Hailong Wang   +8 more
doaj   +1 more source

Effects of 5′,8′-Cyclo-2′-Deoxypurines on the Base Excision Repair of Clustered DNA Lesions in Nuclear Extracts of the XPC Cell Line

Cells, 2021
Clustered DNA lesions (CDL) containing 5′,8-cyclo-2′-deoxypurines (cdPus) are an example of extensive abnormalities occurring in the DNA helix and may impede cellular repair processes.
Julia Kaźmierczak-Barańska, Karolina Boguszewska, Michał Szewczuk, Bolesław T. Karwowski   +3 more
doaj   +1 more source

Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway

BMC Cancer, 2021
Background UEV1A encodes a ubiquitin-E2 variant closely associated with tumorigenesis and metastasis, but its underlying mechanism in promoting metastasis remains to be investigated.
Tong Niu, Zhaojia Wu, Wei Xiao
doaj   +1 more source

Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

Communications Biology, 2023
The Schlafen (SLFN)11 gene has been implicated in various biological processes such as suppression of HIV replication, replication stress response, and sensitization of cancer cells to chemotherapy.
Erin Alvi, Ayako L. Mochizuki, Yoko Katsuki, Minori Ogawa, Fei Qi, Yusuke Okamoto, Minoru Takata, Anfeng Mu   +7 more
doaj   +1 more source

MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer

Cancer Cell International, 2021
Breast cancer is the most common cancer among women and accounts for 30% of all female malignancies worldwide. Breast cancer stem cells (BCSCs) are a small population of breast cancer cells that exhibit multiple characteristics including differentiation ...
Tong Niu, Weiwei Zhang, Wei Xiao
doaj   +1 more source

Lethal DNA damages caused by ion-induced shock waves in cells [PDF]

Phys. Rev. E 104 (2021) 054408, 2021
The elucidation of fundamental mechanisms underlying ion-induced radiation damage of biological systems is crucial for the advancement of radiotherapy with ion beams and for radiation protection in space. The study of ion-induced biodamage using the phenomenon-based MultiScale Approach to the physics of radiation damage with ions (MSA) has led to the ...
arxiv   +1 more source