Results 221 to 230 of about 902,693 (268)
Some of the next articles are maybe not open access.
DNA Methyltransferases and DNA Damage
2022Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
openaire +2 more sources
Photochemistry and Photobiology, 1988
Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
F P, Gasparro, R M, Santella
openaire +2 more sources
Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
F P, Gasparro, R M, Santella
openaire +2 more sources
Journal of the American Chemical Society, 2005
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Sanjay, Dutta +4 more
openaire +2 more sources
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Sanjay, Dutta +4 more
openaire +2 more sources
Critical Reviews in Oncology/Hematology, 2020
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent, Cetin +2 more
openaire +2 more sources
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent, Cetin +2 more
openaire +2 more sources
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012
Carotenoids are among the best known antioxidant phytochemicals, and are widely believed to contribute to the health-promoting properties of fruits and vegetables. Investigations of the effects of carotenoids have been carried out at different levels: in cultured cells, in experimental animals, and in humans.
Amaya, Azqueta, Andrew R, Collins
openaire +2 more sources
Carotenoids are among the best known antioxidant phytochemicals, and are widely believed to contribute to the health-promoting properties of fruits and vegetables. Investigations of the effects of carotenoids have been carried out at different levels: in cultured cells, in experimental animals, and in humans.
Amaya, Azqueta, Andrew R, Collins
openaire +2 more sources
Active DNA demethylation damages DNA
Science, 2022Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage ...
Isaac F, López-Moyado, Anjana, Rao
openaire +2 more sources