Results 231 to 240 of about 5,698,803 (355)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The intersection of TREX1, cGAS, STING and the DNA damage theory of aging. [PDF]

Front Aging
Jones KM, Chauvin SD, Miner JJ.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The Role of Transient Crosslinks in the Chromatin Search Response to DNA Damage. [PDF]

Int J Mol Sci
Atanasiu AT, Hult C, Kolbin D, Walker BL, Forest MG, Yeh E, Bloom K.   +6 more
europepmc   +1 more source

Endogenous DNA Damage as a Source of Genomic Instability in Cancer

Cell, 2017
Anthony Tubbs, A. Nussenzweig
semanticscholar   +1 more source

Connecting androgen receptor signaling and the DNA damage response: Development of new therapies for advanced prostate cancer [PDF]

, 2017
Timothy C. Thompson, Likun Li
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Alkaline Bromodeoxyuridine (BrdU) Comet Assay to Detect Replication-Associated DNA Damage. [PDF]

Curr Protoc
Ribeiro DL, Londero JEL, Martins DJ, Menck CFM.   +3 more
europepmc   +1 more source

The impact of oxidative DNA damage and stress on telomere homeostasis

Mechanisms of Ageing and Development, 2019
Ryan P Barnes, Elise Fouquerel, P. Opresko   +2 more
semanticscholar   +1 more source